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Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex.

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Title: Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex.
Authors: Ossenkoppele R; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. r.ossenkoppele@amsterdamumc.nl.; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands. r.ossenkoppele@amsterdamumc.nl.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands. r.ossenkoppele@amsterdamumc.nl., Coomans EM; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands., Apostolova LG; Indiana University School of Medicine, Indianapolis, IN, USA., Baker SL; Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Barthel H; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany., Beach TG; Banner Sun Health Research Institute, Sun City, AZ, USA., Benzinger TLS; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington, Washington University School of Medicine, St. Louis, MO, USA., Betthauser T; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA., Bischof GN; Faculty of Medicine, University of Cologne and Department of Nuclear Medicine University Hospital Cologne, Cologne, Germany.; Molecular Organization of the Brain, Institute for Neurosciences and Medicine, Jülich, Germany., Bottlaender M; Université Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRS, INSERM, Orsay, France.; UNIACT, Neurospin, CEA, Gif-sur-Yvette, France., Bourgeat P; Australian eHealth Research Centre, CSIRO, Melbourne, Victoria, Australia., den Braber A; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Brendel M; Department of Nuclear Medicine, LMU Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Brickman AM; Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Cash DM; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.; UK Dementia Research Institute at University College London, London, UK., Carrillo MC; Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA., Coath W; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Christian BT; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA., Dickerson BC; Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Thinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA.; Massachusetts Alzheimer's Disease Research Center, Boston, MA, USA., Dore V; Australian eHealth Research Centre, CSIRO, Melbourne, Victoria, Australia.; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia., Drzezga A; Faculty of Medicine, University of Cologne and Department of Nuclear Medicine University Hospital Cologne, Cologne, Germany.; Molecular Organization of the Brain, Institute for Neurosciences and Medicine, Jülich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Feizpour A; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia., van der Flier WM; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Epidemiology and Biostatistics, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands., Franzmeier N; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Neurochemistry, University of Gothenburg, The Sahlgrenska Academy, Institute of Neuroscience and Physiology, Gothenburg, Sweden., Frisoni GB; Memory Clinic, Geneva University Hospitals, Geneva, Switzerland., Garibotto V; Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland.; Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland.; CIBM Center for Biomedical Imaging, Geneva, Switzerland., van de Giessen E; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Radiology & Nuclear Medicine, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands., Domingo-Gispert J; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Madrid, Spain., Gnoerich J; Department of Nuclear Medicine, LMU Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany., Gu Y; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Guan Y; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China., Hanseeuw BJ; Institute of Neuroscience, UCLouvain, Brussels, Belgium.; Department of Neurology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.; Gordon Center for Medical Imaging, Department of Radiology, Mass General Brigham, Boston, MA, USA., Harrison TM; Department of Neuroscience, University of California Berkeley, Berkeley, CA, USA., Jack CR; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Jaeger E; Department of Nuclear Medicine, University of Cologne, University Hospital of Cologne, Cologne, Germany., Jagust WJ; Department of Neuroscience, University of California Berkeley, Berkeley, CA, USA., Jansen WJ; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., La Joie R; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA., Johnson KA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Johnson SC; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Kennedy IA; Eli Lilly and Company, Indianapolis, IN, USA., Kim JP; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., van Laere K; Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging, KU Leuven, Leuven, Belgium.; Division of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium., Lagarde J; Université Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRS, INSERM, Orsay, France.; Department of Neurology of Memory and Language, GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte Anne, Paris, France., Lao P; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Departments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, NY, USA., Luchsinger JA; Departments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, NY, USA., Kern S; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neuropsychiatry, Sahlgrenska University Hospital, Gothenburg, Sweden., Kreisl WC; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Malotaux V; Institute of Neuroscience, UCLouvain, Brussels, Belgium., Malpetti M; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Manly JJ; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Mao X; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China., Mattsson-Carlgren N; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden., Messerschmidt K; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany., Minguillon C; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain., Mormino EM; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., O'Brien JT; Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK., Palmqvist S; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Peretti DE; Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Pijnenburg YAL; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands., Pontecorvo MJ; Eli Lilly and Company, Indianapolis, IN, USA., Poirier J; Douglas Mental Health University Institute, Centre for Studies on the Prevention of Alzheimer's Disease (StoP-AD), Montréal, Québec, Canada.; Department of Psychiatry, McGill University, Montréal, Québec, Canada., Rabinovici GD; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.; Department of Radiology & Biomedical Imaging, University of California, San Francisco, CA, USA., Rahmouni N; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montréal, Québec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montréal, Québec, Canada., Risacher SL; Indiana University, Indianapolis, IN, USA., Rosa-Neto P; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montréal, Québec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montréal, Québec, Canada., Rosen H; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA., Rowe CC; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia., Rowe JB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK., Rullmann M; Clinic for Cognitive Neurology, University Hospital of Leipzig and Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., Salman Y; Institute of Neuroscience, UCLouvain, Brussels, Belgium., Sarazin M; Université Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRS, INSERM, Orsay, France.; Department of Neurology of Memory and Language, GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte-Anne, Paris, France., Saykin AJ; Indiana University, Indianapolis, IN, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Department of Pathology, Rush University Medical Center, Chicago, IL, USA., Schöll M; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.; Department of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden.; Dementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK., Schott JM; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute, London, UK., Seo SW; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Serrano GE; Banner Sun Health Research Institute, Sun City, AZ, USA., Shcherbinin S; Eli Lilly and Company, Indianapolis, IN, USA., Shekari M; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain., Skoog I; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden., Smith R; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Sperling RA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Spruyt L; Laboratory for Cognitive Neurology, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium., Stomrud E; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Strandberg O; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden., Therriault J; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montréal, Québec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montréal, Québec, Canada., Xie F; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China., Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.; Neurology Service, University Hospital Leuven, Leuven, Belgium., Villemagne VL; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Villeneuve S; Douglas Mental Health University Institute, Centre for Studies on the Prevention of Alzheimer's Disease (StoP-AD), Montréal, Québec, Canada.; Department of Psychiatry, McGill University, Montréal, Québec, Canada., Visser PJ; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Vossler H; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Young CB; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Groot C; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands., Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. oskar.hansson@med.lu.se.; Memory Clinic, Skåne University Hospital, Malmö, Sweden. oskar.hansson@med.lu.se.
Corporate Authors: Mayo Clinic Study on Aging, PREVENT-AD Research Group
Source: Nature neuroscience [Nat Neurosci] 2025 Aug; Vol. 28 (8), pp. 1610-1621. Date of Electronic Publication: 2025 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Ossenkoppele+R%22">Ossenkoppele R</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. r.ossenkoppele@amsterdamumc.nl.; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands. r.ossenkoppele@amsterdamumc.nl.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands. r.ossenkoppele@amsterdamumc.nl.<br /><searchLink fieldCode="AU" term="%22Coomans+EM%22">Coomans EM</searchLink>; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Apostolova+LG%22">Apostolova LG</searchLink>; Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Baker+SL%22">Baker SL</searchLink>; Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Barthel+H%22">Barthel H</searchLink>; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Beach+TG%22">Beach TG</searchLink>; Banner Sun Health Research Institute, Sun City, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Benzinger+TLS%22">Benzinger TLS</searchLink>; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Betthauser+T%22">Betthauser T</searchLink>; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Bischof+GN%22">Bischof GN</searchLink>; Faculty of Medicine, University of Cologne and Department of Nuclear Medicine University Hospital Cologne, Cologne, Germany.; Molecular Organization of the Brain, Institute for Neurosciences and Medicine, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Bottlaender+M%22">Bottlaender M</searchLink>; Université Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRS, INSERM, Orsay, France.; UNIACT, Neurospin, CEA, Gif-sur-Yvette, France.<br /><searchLink fieldCode="AU" term="%22Bourgeat+P%22">Bourgeat P</searchLink>; Australian eHealth Research Centre, CSIRO, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22den+Braber+A%22">den Braber A</searchLink>; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Brendel+M%22">Brendel M</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Brickman+AM%22">Brickman AM</searchLink>; Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cash+DM%22">Cash DM</searchLink>; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.; UK Dementia Research Institute at University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Carrillo+MC%22">Carrillo MC</searchLink>; Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Coath+W%22">Coath W</searchLink>; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Christian+BT%22">Christian BT</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Dickerson+BC%22">Dickerson BC</searchLink>; Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Thinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA.; Massachusetts Alzheimer's Disease Research Center, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dore+V%22">Dore V</searchLink>; Australian eHealth Research Centre, CSIRO, Melbourne, Victoria, Australia.; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Drzezga+A%22">Drzezga A</searchLink>; Faculty of Medicine, University of Cologne and Department of Nuclear Medicine University Hospital Cologne, Cologne, Germany.; Molecular Organization of the Brain, Institute for Neurosciences and Medicine, Jülich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Feizpour+A%22">Feizpour A</searchLink>; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22van+der+Flier+WM%22">van der Flier WM</searchLink>; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Epidemiology and Biostatistics, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Franzmeier+N%22">Franzmeier N</searchLink>; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Neurochemistry, University of Gothenburg, The Sahlgrenska Academy, Institute of Neuroscience and Physiology, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Frisoni+GB%22">Frisoni GB</searchLink>; Memory Clinic, Geneva University Hospitals, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Garibotto+V%22">Garibotto V</searchLink>; Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland.; Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland.; CIBM Center for Biomedical Imaging, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22van+de+Giessen+E%22">van de Giessen E</searchLink>; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Radiology & Nuclear Medicine, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Domingo-Gispert+J%22">Domingo-Gispert J</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gnoerich+J%22">Gnoerich J</searchLink>; Department of Nuclear Medicine, LMU Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gu+Y%22">Gu Y</searchLink>; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Guan+Y%22">Guan Y</searchLink>; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Hanseeuw+BJ%22">Hanseeuw BJ</searchLink>; Institute of Neuroscience, UCLouvain, Brussels, Belgium.; Department of Neurology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.; Gordon Center for Medical Imaging, Department of Radiology, Mass General Brigham, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Harrison+TM%22">Harrison TM</searchLink>; Department of Neuroscience, University of California Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jack+CR%22">Jack CR</searchLink>; Department of Radiology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Jaeger+E%22">Jaeger E</searchLink>; Department of Nuclear Medicine, University of Cologne, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Jagust+WJ%22">Jagust WJ</searchLink>; Department of Neuroscience, University of California Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jansen+WJ%22">Jansen WJ</searchLink>; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22La+Joie+R%22">La Joie R</searchLink>; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+KA%22">Johnson KA</searchLink>; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+SC%22">Johnson SC</searchLink>; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Kennedy+IA%22">Kennedy IA</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Kim+JP%22">Kim JP</searchLink>; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22van+Laere+K%22">van Laere K</searchLink>; Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging, KU Leuven, Leuven, Belgium.; Division of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Lagarde+J%22">Lagarde J</searchLink>; Université Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRS, INSERM, Orsay, France.; Department of Neurology of Memory and Language, GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte Anne, Paris, France.<br /><searchLink fieldCode="AU" term="%22Lao+P%22">Lao P</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Departments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Luchsinger+JA%22">Luchsinger JA</searchLink>; Departments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kern+S%22">Kern S</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neuropsychiatry, Sahlgrenska University Hospital, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Kreisl+WC%22">Kreisl WC</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Malotaux+V%22">Malotaux V</searchLink>; Institute of Neuroscience, UCLouvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Malpetti+M%22">Malpetti M</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Manly+JJ%22">Manly JJ</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mao+X%22">Mao X</searchLink>; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Mattsson-Carlgren+N%22">Mattsson-Carlgren N</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Messerschmidt+K%22">Messerschmidt K</searchLink>; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Minguillon+C%22">Minguillon C</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Mormino+EM%22">Mormino EM</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22O'Brien+JT%22">O'Brien JT</searchLink>; Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Palmqvist+S%22">Palmqvist S</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Peretti+DE%22">Peretti DE</searchLink>; Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Petersen+RC%22">Petersen RC</searchLink>; Department of Neurology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pijnenburg+YAL%22">Pijnenburg YAL</searchLink>; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pontecorvo+MJ%22">Pontecorvo MJ</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Poirier+J%22">Poirier J</searchLink>; Douglas Mental Health University Institute, Centre for Studies on the Prevention of Alzheimer's Disease (StoP-AD), Montréal, Québec, Canada.; Department of Psychiatry, McGill University, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Rabinovici+GD%22">Rabinovici GD</searchLink>; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.; Department of Radiology & Biomedical Imaging, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rahmouni+N%22">Rahmouni N</searchLink>; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montréal, Québec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Risacher+SL%22">Risacher SL</searchLink>; Indiana University, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Rosa-Neto+P%22">Rosa-Neto P</searchLink>; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montréal, Québec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Rosen+H%22">Rosen H</searchLink>; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rowe+CC%22">Rowe CC</searchLink>; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Rowe+JB%22">Rowe JB</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rullmann+M%22">Rullmann M</searchLink>; Clinic for Cognitive Neurology, University Hospital of Leipzig and Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Salman+Y%22">Salman Y</searchLink>; Institute of Neuroscience, UCLouvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Sarazin+M%22">Sarazin M</searchLink>; Université Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRS, INSERM, Orsay, France.; Department of Neurology of Memory and Language, GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte-Anne, Paris, France.<br /><searchLink fieldCode="AU" term="%22Saykin+AJ%22">Saykin AJ</searchLink>; Indiana University, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+JA%22">Schneider JA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Department of Pathology, Rush University Medical Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Schöll+M%22">Schöll M</searchLink>; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.; Department of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden.; Dementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Schott+JM%22">Schott JM</searchLink>; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Seo+SW%22">Seo SW</searchLink>; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Serrano+GE%22">Serrano GE</searchLink>; Banner Sun Health Research Institute, Sun City, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Shcherbinin+S%22">Shcherbinin S</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Shekari+M%22">Shekari M</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Skoog+I%22">Skoog I</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Smith+R%22">Smith R</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Sperling+RA%22">Sperling RA</searchLink>; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Spruyt+L%22">Spruyt L</searchLink>; Laboratory for Cognitive Neurology, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Stomrud+E%22">Stomrud E</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Strandberg+O%22">Strandberg O</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Therriault+J%22">Therriault J</searchLink>; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montréal, Québec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Xie+F%22">Xie F</searchLink>; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Vandenberghe+R%22">Vandenberghe R</searchLink>; Laboratory for Cognitive Neurology, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.; Neurology Service, University Hospital Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Villemagne+VL%22">Villemagne VL</searchLink>; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Villeneuve+S%22">Villeneuve S</searchLink>; Douglas Mental Health University Institute, Centre for Studies on the Prevention of Alzheimer's Disease (StoP-AD), Montréal, Québec, Canada.; Department of Psychiatry, McGill University, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Visser+PJ%22">Visser PJ</searchLink>; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vossler+H%22">Vossler H</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Young+CB%22">Young CB</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Groot+C%22">Groot C</searchLink>; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hansson+O%22">Hansson O</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. oskar.hansson@med.lu.se.; Memory Clinic, Skåne University Hospital, Malmö, Sweden. oskar.hansson@med.lu.se.
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  Data: <searchLink fieldCode="JN" term="%229809671%22">Nature neuroscience</searchLink> [Nat Neurosci] 2025 Aug; Vol. 28 (8), pp. 1610-1621. <i>Date of Electronic Publication: </i>2025 Jul 16.
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            NameFull: Serrano GE
      – PersonEntity:
          Name:
            NameFull: Shcherbinin S
      – PersonEntity:
          Name:
            NameFull: Shekari M
      – PersonEntity:
          Name:
            NameFull: Skoog I
      – PersonEntity:
          Name:
            NameFull: Smith R
      – PersonEntity:
          Name:
            NameFull: Sperling RA
      – PersonEntity:
          Name:
            NameFull: Spruyt L
      – PersonEntity:
          Name:
            NameFull: Stomrud E
      – PersonEntity:
          Name:
            NameFull: Strandberg O
      – PersonEntity:
          Name:
            NameFull: Therriault J
      – PersonEntity:
          Name:
            NameFull: Xie F
      – PersonEntity:
          Name:
            NameFull: Vandenberghe R
      – PersonEntity:
          Name:
            NameFull: Villemagne VL
      – PersonEntity:
          Name:
            NameFull: Villeneuve S
      – PersonEntity:
          Name:
            NameFull: Visser PJ
      – PersonEntity:
          Name:
            NameFull: Vossler H
      – PersonEntity:
          Name:
            NameFull: Young CB
      – PersonEntity:
          Name:
            NameFull: Groot C
      – PersonEntity:
          Name:
            NameFull: Hansson O
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: 2025 Aug
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1546-1726
          Numbering:
            – Type: volume
              Value: 28
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Nature neuroscience
              Type: main
ResultId 1