The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.

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Title: The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.
Authors: Jain MK; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA., Gumpper RH; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA., Slocum ST; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA., Schmitz GP; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA., Madsen JS; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark., Tummino TA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA., Suomivuori CM; Department of Computer Science, Stanford University, Stanford, CA 94305, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94304, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA., Huang XP; National Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA., Shub L; Institute of Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA 94158, USA., DiBerto JF; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA., Kim K; Department of System Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea., DeLeon C; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA., Krumm BE; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA., Fay JF; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA., Keiser M; Institute of Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA 94158, USA., Hauser AS; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark., Dror RO; Department of Computer Science, Stanford University, Stanford, CA 94305, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94304, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA., Shoichet B; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA., Gloriam DE; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark., Nichols DE; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA., Roth BL; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA; National Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7365, USA; Divison of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA. Electronic address: bryan_roth@med.unc.edu.
Source: Neuron [Neuron] 2025 Oct 01; Vol. 113 (19), pp. 3129-3142.e9. Date of Electronic Publication: 2025 Jul 18.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4199
DOI:10.1016/j.neuron.2025.06.012