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G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway.

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Title: G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway.
Authors: Meng Q; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Key laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230032, China. mengqian@ahmu.edu.cn., Guo MH; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Key laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230032, China., Zhang R; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Key laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230032, China., Wei J; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Key laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230032, China., Chen Q; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Key laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230032, China., Zhao XC; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Key laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230032, China., Xu CQ; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Key laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230032, China., Wu YY; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Key laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230032, China., Kuai JJ; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Key laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230032, China., Zhao JM; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Key laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230032, China., Wu YJ; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Key laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230032, China., Ye CH; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Key laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230032, China., Wei HR; CAS Key Laboratory of Brain Function and Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China., Zhu X; CAS Key Laboratory of Brain Function and Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China., Jin Y; CAS Key Laboratory of Brain Function and Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China., Zhang Z; CAS Key Laboratory of Brain Function and Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. zhizhang@ustc.edu.cn.; Department of Anatomy, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China. zhizhang@ustc.edu.cn., Wei W; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University, Key laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230032, China. wwei@ahmu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Dec; Vol. 46 (12), pp. 3177-3189. Date of Electronic Publication: 2025 Jul 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-7254
DOI:10.1038/s41401-025-01621-8