Intravenous Thrombolysis in Patients With Recent Intake of Direct Oral Anticoagulants: A Target Trial Analysis and Comparison With Reversal Agent Use.

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Title: Intravenous Thrombolysis in Patients With Recent Intake of Direct Oral Anticoagulants: A Target Trial Analysis and Comparison With Reversal Agent Use.
Authors: Meinel TR; Department of Neurology, Stroke Research Center Bern (T.R.M., P.B., F.Z.-M., U.F., D.J.S.), Inselspital, Bern University Hospital, University of Bern, Switzerland., Bücke P; Department of Neurology, Stroke Research Center Bern (T.R.M., P.B., F.Z.-M., U.F., D.J.S.), Inselspital, Bern University Hospital, University of Bern, Switzerland., D'Anna L; Division of Brain Sciences, Imperial College London, United Kingdom (L.D.)., Merlino G; Clinical Neurology and Stroke Unit, Department of Head, Neck and Neurosciences, Udine University Hospital, Italy (G.M., A.B., L.C., M.V.)., Aguiar de Sousa D; Stroke Centre, Lisbon Central University Hospital Center-ULS São José, Portugal (D.A.d.S., M.E.M., C.G.).; CEEM e Instituto de Anatomia, Faculdade de Medicina, Universidade de Lisboa, Portugal (D.A.d.S., M.E.M., C.G.).; Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal (D.A.d.S., M.E.M., C.G.)., Poli S; Department of Neurology and Stroke (S.P., A.G.-E.), University of Tübingen, Germany.; Hertie Institute for Clinical Brain Research (S.P., A.G.-E.), University of Tübingen, Germany., Purrucker JC; Department of Neurology, Heidelberg University Hospital, Germany (J.C.P., A.K.)., Strambo D; Stroke Center, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (D.S., G.T., P.M.)., Romoli M; Neurology and Stroke Unit, Department of Neurosciences, Bufalini Hospital, AUSL Romagna, Cesena, Italy (M.R., G.S.)., De Marchis GM; Department of Neurology and Stroke Center, University Research and Teaching Hospital, Cantonal Hospital St. Gallen, Switzerland (G.M.D.M., D.V.).; Medical Faculty, University of Basel, Switzerland (G.M.D.M., D.V.)., Pfeilschifter W; Department of Neurology and Clinical Neurophysiology, Klinikum Lueneburg, Germany (W.P., M. Herrmann)., Zedde M; Neurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Italy (M.Z.)., Marto JP; Department of Neurology, Centro Hospitalar Lisboa Ocidental, Hospital de Egas Moniz, Lisbon, Portugal (J.P.M., B.R.)., Candelaresi P; Neurology and Stroke Unit, A.O.R.N. Antonio Cardarelli, Napoli, Italy (P.C., E.S., V.A.)., Lemmens R; Department of Neurosciences, Experimental Neurology, KU Leuven, Belgium (R.L., L.M.).; Department of Neurology, University Hospitals Leuven, Belgium (R.L., L.M.)., Scoppettuolo P; Neurology Department, Cliniques Universitaires Saint Luc-UCL, Bruxelles, Belgique (P.S.)., Woock M; Department of Neurology, Sahlgrenska University Hospital, Göteborg, Sweden (M.W., A.A.)., Kermer P; Department of Neurology, Nordwest-Krankenhaus Sanderbusch, Friesland Kliniken GmbH, Sande and University Medicine Göttingen, Germany (P.K.)., Kristoffersen ES; Department of Neurology, Akershus University Hospital, Lørenskog, Norway (E.S.K.)., Ghannam M; Department of Neurology, University of Iowa Hospitals and Clinics (M.G., Q.N.A.)., Frol S; Department of Vascular Neurology, University Medical Center Ljubljana, Faculty of Medicine, University of Ljubljana, Slovenia (S.F.)., Nolte CH; Department of Neurology with Experimental Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., C.R.)., Yakushiji Y; Department of Neurology, Kansai Medical University, Osaka, Japan (Y.Y., T.K.)., Touzé E; Department of Neurology, CHU de Caen Normandie, France (E.T., M.B.)., Uphaus T; Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany (T.U., M. Hahn)., Mannino M; Department of Neurology and Stroke Unit, AOOR Villa Sofia-V. Cervello, Palermo, Italy (M.M.)., Ntaios G; 1 Propaedeutic Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece (G.N., D.P.)., Padjen V; Neurology Clinic, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Serbia (V.P.)., Henninger N; Department of Neurology, University of Massachusetts Chan Medical School, Worcester (N.H., J.M.)., Zipser-Mohammadzada F; Department of Neurology, Stroke Research Center Bern (T.R.M., P.B., F.Z.-M., U.F., D.J.S.), Inselspital, Bern University Hospital, University of Bern, Switzerland., Mariano ME; Stroke Centre, Lisbon Central University Hospital Center-ULS São José, Portugal (D.A.d.S., M.E.M., C.G.).; CEEM e Instituto de Anatomia, Faculdade de Medicina, Universidade de Lisboa, Portugal (D.A.d.S., M.E.M., C.G.).; Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal (D.A.d.S., M.E.M., C.G.)., Guerreiro C; Stroke Centre, Lisbon Central University Hospital Center-ULS São José, Portugal (D.A.d.S., M.E.M., C.G.).; CEEM e Instituto de Anatomia, Faculdade de Medicina, Universidade de Lisboa, Portugal (D.A.d.S., M.E.M., C.G.).; Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal (D.A.d.S., M.E.M., C.G.)., Burini A; Clinical Neurology and Stroke Unit, Department of Head, Neck and Neurosciences, Udine University Hospital, Italy (G.M., A.B., L.C., M.V.)., Ceccarelli L; Clinical Neurology and Stroke Unit, Department of Head, Neck and Neurosciences, Udine University Hospital, Italy (G.M., A.B., L.C., M.V.)., Valente M; Clinical Neurology and Stroke Unit, Department of Head, Neck and Neurosciences, Udine University Hospital, Italy (G.M., A.B., L.C., M.V.)., Gomez-Exposito A; Department of Neurology and Stroke (S.P., A.G.-E.), University of Tübingen, Germany.; Hertie Institute for Clinical Brain Research (S.P., A.G.-E.), University of Tübingen, Germany., Kleeberg A; Department of Neurology, Heidelberg University Hospital, Germany (J.C.P., A.K.)., Thevoz G; Stroke Center, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (D.S., G.T., P.M.)., Michel P; Stroke Center, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (D.S., G.T., P.M.)., Stufano G; Neurology and Stroke Unit, Department of Neurosciences, Bufalini Hospital, AUSL Romagna, Cesena, Italy (M.R., G.S.)., Vlachos D; Department of Neurology and Stroke Center, University Research and Teaching Hospital, Cantonal Hospital St. Gallen, Switzerland (G.M.D.M., D.V.).; Medical Faculty, University of Basel, Switzerland (G.M.D.M., D.V.)., Herrmann M; Department of Neurology and Clinical Neurophysiology, Klinikum Lueneburg, Germany (W.P., M. Herrmann)., Rodrigues B; Department of Neurology, Centro Hospitalar Lisboa Ocidental, Hospital de Egas Moniz, Lisbon, Portugal (J.P.M., B.R.)., Spina E; Neurology and Stroke Unit, A.O.R.N. Antonio Cardarelli, Napoli, Italy (P.C., E.S., V.A.)., Andreone V; Neurology and Stroke Unit, A.O.R.N. Antonio Cardarelli, Napoli, Italy (P.C., E.S., V.A.)., Allardt A; Department of Neurology, Sahlgrenska University Hospital, Göteborg, Sweden (M.W., A.A.)., Alshaer QN; Department of Neurology, University of Iowa Hospitals and Clinics (M.G., Q.N.A.)., Riegler C; Department of Neurology with Experimental Neurology and Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germany (C.H.N., C.R.)., Kunieda T; Department of Neurology, Kansai Medical University, Osaka, Japan (Y.Y., T.K.)., Boulanger M; Department of Neurology, CHU de Caen Normandie, France (E.T., M.B.)., Hahn M; Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany (T.U., M. Hahn)., Papadimitriou D; 1 Propaedeutic Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece (G.N., D.P.)., Muppa J; Department of Neurology, University of Massachusetts Chan Medical School, Worcester (N.H., J.M.)., Maes L; Department of Neurosciences, Experimental Neurology, KU Leuven, Belgium (R.L., L.M.).; Department of Neurology, University Hospitals Leuven, Belgium (R.L., L.M.)., Ranta A; Department of Neurology, Wellington Hospital, New Zealand (A.R., A.T.)., Tyson A; Department of Neurology, Wellington Hospital, New Zealand (A.R., A.T.)., Barber PA; Department of Medicine, University of Auckland, New Zealand (P.A.B.)., Davis AJ; Department of Medicine, Whangarei Hospital, New Zealand (A.J.D.)., Wu TY; Department of Neurology, Christchurch Hospital, New Zealand (T.Y.W.)., Kaesmacher J; University Institute of Diagnostic and Interventional Neuroradiology (J.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland.; Diagnostic and Interventional Neuroradiology, Tours, France (J.K.).; Le Studium Loire Valley Institute for Advanced Studies, Orléans, France (J.K.)., Fischer U; Department of Neurology, Stroke Research Center Bern (T.R.M., P.B., F.Z.-M., U.F., D.J.S.), Inselspital, Bern University Hospital, University of Bern, Switzerland., Seiffge DJ; Department of Neurology, Stroke Research Center Bern (T.R.M., P.B., F.Z.-M., U.F., D.J.S.), Inselspital, Bern University Hospital, University of Bern, Switzerland.
Corporate Authors: International DO-IT Collaboration
Source: Stroke [Stroke] 2025 Oct; Vol. 56 (10), pp. 2836-2845. Date of Electronic Publication: 2025 Jul 22.
Publication Type: Journal Article; Comparative Study; Multicenter Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0235266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4628 (Electronic) Linking ISSN: 00392499 NLM ISO Abbreviation: Stroke Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1524-4628
DOI:10.1161/STROKEAHA.125.051384