Mitochondrial dysfunction drives basal cell hyperplasia in eosinophilic oesophagitis.

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Title: Mitochondrial dysfunction drives basal cell hyperplasia in eosinophilic oesophagitis.
Authors: Morimoto M; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA., Kawasaki K; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA., McNamee N; Massachusetts General Hospital, Boston, Massachusetts, USA., Flashner S; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA., Shimonosono R; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA., Shimonosono M; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA., Matsuura N; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA., Tomita Y; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA., Hirose W; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA., Teranishi R; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Itami T; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Guha M; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA., Rajagopalan P; Massachusetts General Hospital, Boston, Massachusetts, USA., Martin C; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA.; Division of Digestive & Liver Diseases, Department of Medicine, Columbia University, New York, New York, USA.; Digestive & Liver Disease Research Center, Columbia University, New York, New York, USA., Golden H; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Dhakal D; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Wilkins BJ; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Klein-Szanto AJ; Histopathology Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA., Wangensteen KJ; Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Abrams JA; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA.; Division of Digestive & Liver Diseases, Department of Medicine, Columbia University, New York, New York, USA.; Digestive & Liver Disease Research Center, Columbia University, New York, New York, USA., Pomenti S; Division of Digestive & Liver Diseases, Department of Medicine, Columbia University, New York, New York, USA., Katzka DA; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA.; Division of Digestive & Liver Diseases, Department of Medicine, Columbia University, New York, New York, USA., Que J; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA.; Division of Digestive & Liver Diseases, Department of Medicine, Columbia University, New York, New York, USA., Whelan KA; Fels Cancer Institute for Personalized Medicine, Department of Cancer & Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA., Muir AB; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Kita H; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Wright BL; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Doyle AD; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Nakagawa H; Columbia University Herbert Irving Comprehensive Cancer Center, New York, New York, USA uma.sachdeva@mgh.harvard.edu hn2360@cumc.columbia.edu.; Division of Digestive & Liver Diseases, Department of Medicine, Columbia University, New York, New York, USA.; Digestive & Liver Disease Research Center, Columbia University, New York, New York, USA., Sachdeva UM; Massachusetts General Hospital, Boston, Massachusetts, USA uma.sachdeva@mgh.harvard.edu hn2360@cumc.columbia.edu.; Thoracic Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Source: Gut [Gut] 2025 Sep 08; Vol. 74 (10), pp. 1571-1588. Date of Electronic Publication: 2025 Sep 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1468-3288
DOI:10.1136/gutjnl-2024-334561