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Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.

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Title: Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.
Authors: Sinha IR; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sandal PS; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Spence H; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK., Burns GD; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mallika AP; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Abbasinejad F; Scientific Software Engineering Center, Johns Hopkins University, Baltimore, MD, USA., Irwin KE; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Cruz ALF; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Wang V; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA., Marx SR; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; University of Florida College of Medicine, Gainesville, FL, USA., Rodríguez JL; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Langmead B; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA., Gregory JM; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; Department of Pathology, NHS Grampian Tissue Biorepository, Aberdeen, UK., Wong PC; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ling JP; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jling@jhu.edu.
Source: Nature communications [Nat Commun] 2025 Jul 25; Vol. 16 (1), pp. 6878. Date of Electronic Publication: 2025 Jul 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.
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