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Eosinophils as a predictive marker of treatment-related adverse events in mRCC patients treated with first-line immune-checkpoint inhibitor combination therapy.

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Title: Eosinophils as a predictive marker of treatment-related adverse events in mRCC patients treated with first-line immune-checkpoint inhibitor combination therapy.
Authors: Kawada T; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Katayama S; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Yanagisawa T; Department of Urology, The Jikei University School of Medicine, Tokyo, Japan., Mori K; Department of Urology, The Jikei University School of Medicine, Tokyo, Japan., Fukuokaya W; Department of Urology, The Jikei University School of Medicine, Tokyo, Japan., Komura K; Department of Urology, Osaka Medical and Pharmaceutical University, Osaka, Japan., Tsujino T; Department of Urology, Osaka Medical and Pharmaceutical University, Osaka, Japan., Maenosono R; Department of Urology, Osaka Medical and Pharmaceutical University, Osaka, Japan., Takahara K; Department of Urology, Fujita Health University School of Medicine, Aichi, Japan., Nukaya T; Department of Urology, Fujita Health University School of Medicine, Aichi, Japan., Inoki L; Department of Urology, Kindai University Faculty of Medicine, Osaka, Japan., Toyoda S; Department of Urology, Kindai University Faculty of Medicine, Osaka, Japan., Hashimoto T; Department of Urology, Tokyo Medical University, Tokyo, Japan., Hirasawa Y; Department of Urology, Tokyo Medical University, Tokyo, Japan., Edamura K; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Kobayashi T; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Bekku K; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Nishimura S; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Iwata T; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Sadahira T; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Tominaga Y; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Yamanoi T; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Yoshinaga K; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Tsuboi K; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Kobayashi Y; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Takamoto A; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Kurose K; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Kimura T; Department of Urology, The Jikei University School of Medicine, Tokyo, Japan., Azuma H; Department of Urology, Osaka Medical and Pharmaceutical University, Osaka, Japan., Shiroki R; Department of Urology, Fujita Health University School of Medicine, Aichi, Japan., Fujita K; Department of Urology, Kindai University Faculty of Medicine, Osaka, Japan., Ohno Y; Department of Urology, Tokyo Medical University, Tokyo, Japan., Araki M; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan. motoosh@md.okayama-u.ac.jp.
Corporate Authors: JK-FOOT study group
Source: Scientific reports [Sci Rep] 2025 Jul 25; Vol. 15 (1), pp. 27163. Date of Electronic Publication: 2025 Jul 25.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-025-08767-9