SETDB1 knockdown boosts recombinant protein in CHO cells via epigenetic transcriptional silencing.
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| Title: | SETDB1 knockdown boosts recombinant protein in CHO cells via epigenetic transcriptional silencing. |
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| Authors: | Lu JT; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Zhang M; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Gao YP; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Yang LL; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Cui ZM; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Han MM; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Zhang X; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Xu HY; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Wang XY; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Qiu LL; School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Hua ZC; Department of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; School of Life Sciences, Nanjing University, Nanjing, 210023, Jiangsu, China., Wang TY; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China. wtianyuncn@126.com.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China. wtianyuncn@126.com.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China. wtianyuncn@126.com., Jia YL; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China. yanlongjia@126.com.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China. yanlongjia@126.com.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China. yanlongjia@126.com.; Department of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China. yanlongjia@126.com. |
| Source: | AMB Express [AMB Express] 2025 Jul 26; Vol. 15 (1), pp. 110. Date of Electronic Publication: 2025 Jul 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101561785 Publication Model: Electronic Cited Medium: Print ISSN: 2191-0855 (Print) Linking ISSN: 21910855 NLM ISO Abbreviation: AMB Express Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2191-0855 |
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| DOI: | 10.1186/s13568-025-01914-5 |
