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SETDB1 knockdown boosts recombinant protein in CHO cells via epigenetic transcriptional silencing.

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Title: SETDB1 knockdown boosts recombinant protein in CHO cells via epigenetic transcriptional silencing.
Authors: Lu JT; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Zhang M; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Gao YP; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Yang LL; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Cui ZM; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Han MM; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Zhang X; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Xu HY; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Wang XY; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Qiu LL; School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Hua ZC; Department of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; School of Life Sciences, Nanjing University, Nanjing, 210023, Jiangsu, China., Wang TY; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China. wtianyuncn@126.com.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China. wtianyuncn@126.com.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China. wtianyuncn@126.com., Jia YL; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China. yanlongjia@126.com.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China. yanlongjia@126.com.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China. yanlongjia@126.com.; Department of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China. yanlongjia@126.com.
Source: AMB Express [AMB Express] 2025 Jul 26; Vol. 15 (1), pp. 110. Date of Electronic Publication: 2025 Jul 26.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101561785 Publication Model: Electronic Cited Medium: Print ISSN: 2191-0855 (Print) Linking ISSN: 21910855 NLM ISO Abbreviation: AMB Express Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: SETDB1 knockdown boosts recombinant protein in CHO cells via epigenetic transcriptional silencing.
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  Data: <searchLink fieldCode="AU" term="%22Lu+JT%22">Lu JT</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Gao+YP%22">Gao YP</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Yang+LL%22">Yang LL</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Cui+ZM%22">Cui ZM</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Han+MM%22">Han MM</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Xu+HY%22">Xu HY</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Wang+XY%22">Wang XY</searchLink>; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Qiu+LL%22">Qiu LL</searchLink>; School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Hua+ZC%22">Hua ZC</searchLink>; Department of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China.; School of Life Sciences, Nanjing University, Nanjing, 210023, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Wang+TY%22">Wang TY</searchLink>; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China. wtianyuncn@126.com.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China. wtianyuncn@126.com.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China. wtianyuncn@126.com.<br /><searchLink fieldCode="AU" term="%22Jia+YL%22">Jia YL</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China. yanlongjia@126.com.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, 453003, Henan, China. yanlongjia@126.com.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, 453003, Henan, China. yanlongjia@126.com.; Department of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China. yanlongjia@126.com.
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  Data: <searchLink fieldCode="JN" term="%22101561785%22">AMB Express</searchLink> [AMB Express] 2025 Jul 26; Vol. 15 (1), pp. 110. <i>Date of Electronic Publication: </i>2025 Jul 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101561785 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2191-0855 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221910855%22">21910855 </searchLink><i>NLM ISO Abbreviation: </i>AMB Express <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1186/s13568-025-01914-5
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              Text: 2025 Jul 26
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