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Novel Benzenesulfonamide Derivatives of 5'-Aminospirotriazolotriazine Exhibit Anti-Inflammatory Activity by Suppressing Pro-Inflammatory Mediators: In Vitro and In Vivo Evaluation Using a Rat Model of Carrageenan-Induced Paw Edema.

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Title: Novel Benzenesulfonamide Derivatives of 5'-Aminospirotriazolotriazine Exhibit Anti-Inflammatory Activity by Suppressing Pro-Inflammatory Mediators: In Vitro and In Vivo Evaluation Using a Rat Model of Carrageenan-Induced Paw Edema.
Authors: Hamed AM; Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt., Enaili SS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Zawia, Al Zawia 16418, Libya., I Mohammed W; Department of Clinical Pharmacology, Faculty of Medicine, Sohag University, Sohag 82524, Egypt., Abouelella AMA; Department of Clinical Pharmacology, Faculty of Medicine, Sohag University, Sohag 82524, Egypt., Mohana ZEE; College of Medicine, Alexandria University, Alexandria 26571, Egypt., Monir DM; Physiology Department, Faculty of Medicine, Sohag University, Sohag 82524, Egypt., Soliman SS; Department of Zoology, Faculty of Science, Minia University, Minya 61519, Egypt., Hamouda EEM; Department of Pathology, College of Veterinary Medicine, Alexandria University, Alexandria 26571, Egypt., Elatif HMA; Department of Clinical Pharmacology, Faculty of Medicine, Sohag University, Sohag 82524, Egypt.; Department of Basic Medical Science, Al Rayan National College of Medicine, Madinah 41411, Saudi Arabia., El-Saghier AM; Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt.
Source: Biomedicines [Biomedicines] 2025 Jul 15; Vol. 13 (7). Date of Electronic Publication: 2025 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel Benzenesulfonamide Derivatives of 5'-Aminospirotriazolotriazine Exhibit Anti-Inflammatory Activity by Suppressing Pro-Inflammatory Mediators: In Vitro and In Vivo Evaluation Using a Rat Model of Carrageenan-Induced Paw Edema.
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  Data: <searchLink fieldCode="AU" term="%22Hamed+AM%22">Hamed AM</searchLink>; Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt.<br /><searchLink fieldCode="AU" term="%22Enaili+SS%22">Enaili SS</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Zawia, Al Zawia 16418, Libya.<br /><searchLink fieldCode="AU" term="%22I+Mohammed+W%22">I Mohammed W</searchLink>; Department of Clinical Pharmacology, Faculty of Medicine, Sohag University, Sohag 82524, Egypt.<br /><searchLink fieldCode="AU" term="%22Abouelella+AMA%22">Abouelella AMA</searchLink>; Department of Clinical Pharmacology, Faculty of Medicine, Sohag University, Sohag 82524, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohana+ZEE%22">Mohana ZEE</searchLink>; College of Medicine, Alexandria University, Alexandria 26571, Egypt.<br /><searchLink fieldCode="AU" term="%22Monir+DM%22">Monir DM</searchLink>; Physiology Department, Faculty of Medicine, Sohag University, Sohag 82524, Egypt.<br /><searchLink fieldCode="AU" term="%22Soliman+SS%22">Soliman SS</searchLink>; Department of Zoology, Faculty of Science, Minia University, Minya 61519, Egypt.<br /><searchLink fieldCode="AU" term="%22Hamouda+EEM%22">Hamouda EEM</searchLink>; Department of Pathology, College of Veterinary Medicine, Alexandria University, Alexandria 26571, Egypt.<br /><searchLink fieldCode="AU" term="%22Elatif+HMA%22">Elatif HMA</searchLink>; Department of Clinical Pharmacology, Faculty of Medicine, Sohag University, Sohag 82524, Egypt.; Department of Basic Medical Science, Al Rayan National College of Medicine, Madinah 41411, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22El-Saghier+AM%22">El-Saghier AM</searchLink>; Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt.
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  Data: <searchLink fieldCode="JN" term="%22101691304%22">Biomedicines</searchLink> [Biomedicines] 2025 Jul 15; Vol. 13 (7). <i>Date of Electronic Publication: </i>2025 Jul 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI+AG%22">MDPI AG </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101691304 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2227-9059 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222279059%22">22279059 </searchLink><i>NLM ISO Abbreviation: </i>Biomedicines <i>Subsets: </i>PubMed not MEDLINE
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      – TitleFull: Novel Benzenesulfonamide Derivatives of 5'-Aminospirotriazolotriazine Exhibit Anti-Inflammatory Activity by Suppressing Pro-Inflammatory Mediators: In Vitro and In Vivo Evaluation Using a Rat Model of Carrageenan-Induced Paw Edema.
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              Text: 2025 Jul 15
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