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Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models.

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Title: Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models.
Authors: Ramezani-Rad P; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA., Cottrell CA; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Marina-Zárate E; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA., Liguori A; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA., Landais E; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA., Torres JL; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Myers A; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA., Lee JH; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA., Baboo S; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA., Flynn C; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA., McKenney K; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA., Salcedo E; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA., Zhou X; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA., Kalyuzhniy O; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA., Georgeson E; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Phelps N; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Lu D; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Eskandarzadeh S; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Menis S; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA., Kubitz M; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Groschel B; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA., Alavi N; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Jackson AM; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Lee WH; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Tran AS; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Ben-Akiva E; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Kaczmarek Michaels K; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Diedrich JK; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA., Enemuo CA; Emory National Primate Research Center and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA., Lewis V; Emory National Primate Research Center and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA., Pradhan A; Emory National Primate Research Center and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA., Kasturi SP; Emory National Primate Research Center and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA., Schiffner T; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA., Steichen JM; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA., Carnathan DG; Emory National Primate Research Center and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA., Himansu S; Moderna Inc., Cambridge, MA 02142, USA., Yates JR 3rd; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA., Paulson JC; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA., Ozorowski G; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Irvine DJ; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Silvestri G; Emory National Primate Research Center and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA., Sok D; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA., Ward AB; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Crotty S; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA., Schief WR; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, San Diego, CA 92121, USA.; Moderna Inc., Cambridge, MA 02142, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Jul 30; Vol. 17 (809), pp. eadw0721. Date of Electronic Publication: 2025 Jul 30.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.adw0721