Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial.
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| Title: | Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial. |
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| Authors: | Parks KR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Moodie Z; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Allen MA; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA., Yen C; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA., Furch BD; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., MacPhee KJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Ozorowski G; Department of Integrative, Structural, and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Heptinstall J; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics, and Microbiology, Duke University, Durham, NC 27701, USA., Hahn WO; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Zheng Z; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Lu H; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Grant S; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Domin E; Duke University Medical Center, Durham, NC 27701, USA., Duff MO; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Seese A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Marini-Macouzet C; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Ballweber-Fleming L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Lee WH; Department of Integrative, Structural, and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Cottrell CA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037 USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Liguori A; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037 USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Georgeson E; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037 USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Alavi N; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037 USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Kubitz M; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037 USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Phelps N; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037 USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Seaton KE; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics, and Microbiology, Duke University, Durham, NC 27701, USA., Cohen KW; Moderna, 325 Binney Street, Cambridge, MA 02142, USA., Anderson MA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Mondal K; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Laufer DS; IAVI, New York, NY 10004, USA., Kublin JG; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Ward AB; Department of Integrative, Structural, and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Hyrien O; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA., De Rosa SC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA., Himansu S; Moderna, 325 Binney Street, Cambridge, MA 02142, USA., Leav B; Moderna, 325 Binney Street, Cambridge, MA 02142, USA., Reuter C; Moderna, 325 Binney Street, Cambridge, MA 02142, USA., Tomaras GD; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics, and Microbiology, Duke University, Durham, NC 27701, USA., Montefiori D; Duke University Medical Center, Durham, NC 27701, USA., Walsh SR; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Frank I; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Sobieszczyk ME; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Goepfert PA; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA., Stephenson KE; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Baden LR; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Van Tieu H; New York Blood Center, New York, NY 10017, USA., Keefer MC; Infectious Diseases Division, Department of Medicine, University of Rochester, Rochester, NY 14627, USA., Clark J; Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA., Riddler SA; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Schief WR; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037 USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Moderna, 325 Binney Street, Cambridge, MA 02142, USA., McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Medicine, University of Washington, Seattle, WA 98195, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2025 Jul 30; Vol. 17 (809), pp. eady6831. Date of Electronic Publication: 2025 Jul 30. |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.ady6831 |
