Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR.
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| Title: | Cryo-EM reveals an extrahelical allosteric binding site at the M |
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| Authors: | Burger WAC; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia., Mobbs JI; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia., Rana B; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia., Wang J; Computational Medicine Program and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA., Joshi K; Computational Medicine Program and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA., Gentry PR; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia., Yeasmin M; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia., Venugopal H; Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, Vic, Australia., Bender AM; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery and Department of Chemistry, Vanderbilt University, Nashville, TN, USA., Lindsley CW; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery and Department of Chemistry, Vanderbilt University, Nashville, TN, USA., Miao Y; Computational Medicine Program and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA. Yinglong_Miao@med.unc.edu., Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia. arthur.christopoulos@monash.edu.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia. arthur.christopoulos@monash.edu.; Neuromedicines Discovery Centre, Monash University, Parkville, Vic, Australia. arthur.christopoulos@monash.edu., Valant C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia. celine.valant@monash.edu.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia. celine.valant@monash.edu., Thal DM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia. david.thal@monash.edu.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia. david.thal@monash.edu. |
| Source: | Nature communications [Nat Commun] 2025 Jul 31; Vol. 16 (1), pp. 7046. Date of Electronic Publication: 2025 Jul 31. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-62212-z |
