Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies.

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Title: Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies.
Authors: Lederhofer J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Borst AJ; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA., Nguyen L; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Gillespie RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Williams CJ; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA., Walker EL; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA., Raab JE; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Yap C; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Ellis D; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.; Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, WA, 98195, USA., Creanga A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Tan HX; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia., Do THT; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia., Ravichandran M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., McDermott AB; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Le Sage V; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA., Andrews SF; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Graham BS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Wheatley AK; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia., Reed DS; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA., King NP; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA. neilking@uw.edu.; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA. neilking@uw.edu., Kanekiyo M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA. kanekiyom@nih.gov.
Source: Nature communications [Nat Commun] 2025 Aug 01; Vol. 16 (1), pp. 7068. Date of Electronic Publication: 2025 Aug 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-62339-z