HEP14 treatment improves ovarian function in aged mice through mitophagy enhancement and oxidative stress reduction.

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Title: HEP14 treatment improves ovarian function in aged mice through mitophagy enhancement and oxidative stress reduction.
Authors: Gui L; Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China. dawnkwei@163.com.; Institute of Obstetrics and Gynecology, Shenzhen Peking University-Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Shenzhen, China. dawnkwei@163.com.; Centre for Tissue Engineering and Stem Cell Research, Guizhou Medical University, Guiyang, China. dawnkwei@163.com., Sun J; Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.; Institute of Obstetrics and Gynecology, Shenzhen Peking University-Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Shenzhen, China., Zhong Q; Centre for Tissue Engineering and Stem Cell Research, Guizhou Medical University, Guiyang, China.; Clinical Medical Research Center, Affiliated Hospital of Guizhou Medical University, Guiyang City, Guizhou Province, China., Liu K; Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.; Institute of Obstetrics and Gynecology, Shenzhen Peking University-Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Shenzhen, China., Sun Q; Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China., Di Y; State Key Laboratory of Phytochemistry and Plant Resource in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China., Picton H; Reproduction and Early Development Research Group, Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK., Tang B; Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China. tangb@sustech.edu.cn., Hao X; State Key Laboratory of Phytochemistry and Plant Resource in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China. haoxj@mail.kib.ac.cn., Li C; Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China. 15168888909@163.com.; Institute of Obstetrics and Gynecology, Shenzhen Peking University-Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Shenzhen, China. 15168888909@163.com.
Source: Communications biology [Commun Biol] 2025 Aug 01; Vol. 8 (1), pp. 1141. Date of Electronic Publication: 2025 Aug 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2399-3642
DOI:10.1038/s42003-025-08576-w