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Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease.

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Title: Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease.
Authors: Babygirija R; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Cellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA., Han JH; Cellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA., Sonsalla MM; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Comparative Biomedical Sciences Graduate Program, University of Wisconsin-Madison, Madison, WI, USA., Matoska R; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Calubag MF; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Cellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA., Green CL; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Tobon A; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Yeh CY; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Vertein D; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA., Schlorf S; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Illiano J; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Wisconsin Surgical Laboratory in Metabolism, Department of Surgery, University of Wisconsin-Madison, Madison, WI, USA., Liu Y; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Endocrinology and Reproductive Physiology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA., Grunow I; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Rigby MJ; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA., Puglielli L; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Nathan Shock Center of Excellence in the Basic Biology of Aging, Madison, WI, USA., Harris DA; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Wisconsin Surgical Laboratory in Metabolism, Department of Surgery, University of Wisconsin-Madison, Madison, WI, USA.; University of Wisconsin Comprehensive Diabetes Center, Madison, WI, USA.; Wisconsin Nathan Shock Center of Excellence in the Basic Biology of Aging, Madison, WI, USA., Denu JM; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Nathan Shock Center of Excellence in the Basic Biology of Aging, Madison, WI, USA., Lamming DW; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA. dlamming@medicine.wisc.edu.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. dlamming@medicine.wisc.edu.; Cellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA. dlamming@medicine.wisc.edu.; Comparative Biomedical Sciences Graduate Program, University of Wisconsin-Madison, Madison, WI, USA. dlamming@medicine.wisc.edu.; Endocrinology and Reproductive Physiology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA. dlamming@medicine.wisc.edu.; University of Wisconsin Comprehensive Diabetes Center, Madison, WI, USA. dlamming@medicine.wisc.edu.; Wisconsin Nathan Shock Center of Excellence in the Basic Biology of Aging, Madison, WI, USA. dlamming@medicine.wisc.edu.; University of Wisconsin Carbone Cancer Center, Madison, WI, USA. dlamming@medicine.wisc.edu.
Source: Nature communications [Nat Commun] 2025 Aug 04; Vol. 16 (1), pp. 7147. Date of Electronic Publication: 2025 Aug 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Babygirija+R%22">Babygirija R</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Cellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Han+JH%22">Han JH</searchLink>; Cellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Sonsalla+MM%22">Sonsalla MM</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Comparative Biomedical Sciences Graduate Program, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Matoska+R%22">Matoska R</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. 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Middleton Memorial Veterans Hospital, Madison, WI, USA.; Wisconsin Surgical Laboratory in Metabolism, Department of Surgery, University of Wisconsin-Madison, Madison, WI, USA.; University of Wisconsin Comprehensive Diabetes Center, Madison, WI, USA.; Wisconsin Nathan Shock Center of Excellence in the Basic Biology of Aging, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Denu+JM%22">Denu JM</searchLink>; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Nathan Shock Center of Excellence in the Basic Biology of Aging, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Lamming+DW%22">Lamming DW</searchLink>; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA. dlamming@medicine.wisc.edu.; William S. 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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Aug 04; Vol. 16 (1), pp. 7147. <i>Date of Electronic Publication: </i>2025 Aug 04.
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