Reduced Sphingosine-1-Phosphate Levels Exacerbate Type 2 Diabetes Mellitus and Associated Complications in a High-Fat Diet Mouse Model.

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Title: Reduced Sphingosine-1-Phosphate Levels Exacerbate Type 2 Diabetes Mellitus and Associated Complications in a High-Fat Diet Mouse Model.
Authors: Hsu SC; Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan., Chen CL; Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan., Liu CT; Division of Nephrology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Lo HC; Division of Trauma and Emergency Surgery, Department of Surgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan.; Weight Management Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan., Liu YK; Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Gao PS; Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Huang SK; Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan., Hsu CW; Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. wan11119@gmail.com.; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. wan11119@gmail.com.
Source: Endocrinology and metabolism (Seoul, Korea) [Endocrinol Metab (Seoul)] 2026 Feb; Vol. 41 (1), pp. 108-120. Date of Electronic Publication: 2025 Aug 05.
Publication Type: Journal Article
Journal Info: Publisher: Korean Endocrine Society Country of Publication: Korea (South) NLM ID: 101554139 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2093-5978 (Electronic) Linking ISSN: 2093596X NLM ISO Abbreviation: Endocrinol Metab (Seoul) Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2093-5978
DOI:10.3803/EnM.2025.2360