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Reduced Sphingosine-1-Phosphate Levels Exacerbate Type 2 Diabetes Mellitus and Associated Complications in a High-Fat Diet Mouse Model.

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Title: Reduced Sphingosine-1-Phosphate Levels Exacerbate Type 2 Diabetes Mellitus and Associated Complications in a High-Fat Diet Mouse Model.
Authors: Hsu SC; Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan., Chen CL; Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan., Liu CT; Division of Nephrology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Lo HC; Division of Trauma and Emergency Surgery, Department of Surgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan.; Weight Management Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan., Liu YK; Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Gao PS; Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Huang SK; Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan., Hsu CW; Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. wan11119@gmail.com.; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. wan11119@gmail.com.
Source: Endocrinology and metabolism (Seoul, Korea) [Endocrinol Metab (Seoul)] 2026 Feb; Vol. 41 (1), pp. 108-120. Date of Electronic Publication: 2025 Aug 05.
Publication Type: Journal Article
Journal Info: Publisher: Korean Endocrine Society Country of Publication: Korea (South) NLM ID: 101554139 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2093-5978 (Electronic) Linking ISSN: 2093596X NLM ISO Abbreviation: Endocrinol Metab (Seoul) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Reduced Sphingosine-1-Phosphate Levels Exacerbate Type 2 Diabetes Mellitus and Associated Complications in a High-Fat Diet Mouse Model.
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  Data: <searchLink fieldCode="AU" term="%22Hsu+SC%22">Hsu SC</searchLink>; Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CL%22">Chen CL</searchLink>; Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+CT%22">Liu CT</searchLink>; Division of Nephrology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lo+HC%22">Lo HC</searchLink>; Division of Trauma and Emergency Surgery, Department of Surgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan.; Weight Management Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+YK%22">Liu YK</searchLink>; Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Gao+PS%22">Gao PS</searchLink>; Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Huang+SK%22">Huang SK</searchLink>; Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+CW%22">Hsu CW</searchLink>; Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. wan11119@gmail.com.; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. wan11119@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101554139%22">Endocrinology and metabolism (Seoul, Korea)</searchLink> [Endocrinol Metab (Seoul)] 2026 Feb; Vol. 41 (1), pp. 108-120. <i>Date of Electronic Publication: </i>2025 Aug 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Korean+Endocrine+Society%22">Korean Endocrine Society </searchLink><i>Country of Publication: </i>Korea (South) <i>NLM ID: </i>101554139 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2093-5978 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222093596X%22">2093596X </searchLink><i>NLM ISO Abbreviation: </i>Endocrinol Metab (Seoul) <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40761087
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      – Type: doi
        Value: 10.3803/EnM.2025.2360
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      – Code: eng
        Text: English
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      – TitleFull: Reduced Sphingosine-1-Phosphate Levels Exacerbate Type 2 Diabetes Mellitus and Associated Complications in a High-Fat Diet Mouse Model.
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              Text: 2026 Feb
              Type: published
              Y: 2026
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