TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasis.
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| Title: | TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasis. |
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| Authors: | Cave DD; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy. donatella.dellecave@igb.cnr.it., Di Domenico A; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Fantuz M; Department of Biology, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy., Ciotola M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Mangini M; Institute of Endotypes in Oncology, Metabolism and Immunology 'G. Salvatore' (IEOMI), Second Unit, Naples, Italy., Buonaiuto S; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Corrado B; Interdisciplinary Research Centre on Biomaterials, University of Naples Federico II, Naples, Italy., Corona M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Saracino F; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Andolfi G; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Di Biase I; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Cucciardi A; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Carrer A; Department of Biology, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy., Sainz B Jr; Department of Cancer, Instituto de Investigaciones Biomedicas Sols-Morreale (IIBM), CSIC-UAM, Madrid, Spain.; Cancer Area 3-Instituto Ramon Y Cajal de Investigacion Sanitaria (IRYCIS), Madrid, Spain.; Centro de Investigación Biomédica en Red, Área Cáncer, CIBERONC, ISCIII, Madrid, Spain., Pirozzi T; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Re DL; Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, Universidad de Granada, Granada, Spain., Colonna V; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Minchiotti G; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., De Luca AC; Institute of Endotypes in Oncology, Metabolism and Immunology 'G. Salvatore' (IEOMI), Second Unit, Naples, Italy., Lonardo E; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy. enza.lonardo@igb.cnr.it. |
| Source: | Cell death & disease [Cell Death Dis] 2025 Aug 06; Vol. 16 (1), pp. 592. Date of Electronic Publication: 2025 Aug 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-025-07859-8 |
