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TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasis.

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Title: TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasis.
Authors: Cave DD; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy. donatella.dellecave@igb.cnr.it., Di Domenico A; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Fantuz M; Department of Biology, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy., Ciotola M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Mangini M; Institute of Endotypes in Oncology, Metabolism and Immunology 'G. Salvatore' (IEOMI), Second Unit, Naples, Italy., Buonaiuto S; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Corrado B; Interdisciplinary Research Centre on Biomaterials, University of Naples Federico II, Naples, Italy., Corona M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Saracino F; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Andolfi G; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Di Biase I; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Cucciardi A; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Carrer A; Department of Biology, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy., Sainz B Jr; Department of Cancer, Instituto de Investigaciones Biomedicas Sols-Morreale (IIBM), CSIC-UAM, Madrid, Spain.; Cancer Area 3-Instituto Ramon Y Cajal de Investigacion Sanitaria (IRYCIS), Madrid, Spain.; Centro de Investigación Biomédica en Red, Área Cáncer, CIBERONC, ISCIII, Madrid, Spain., Pirozzi T; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., Re DL; Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, Universidad de Granada, Granada, Spain., Colonna V; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Minchiotti G; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy., De Luca AC; Institute of Endotypes in Oncology, Metabolism and Immunology 'G. Salvatore' (IEOMI), Second Unit, Naples, Italy., Lonardo E; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy. enza.lonardo@igb.cnr.it.
Source: Cell death & disease [Cell Death Dis] 2025 Aug 06; Vol. 16 (1), pp. 592. Date of Electronic Publication: 2025 Aug 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasis.
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  Data: <searchLink fieldCode="AU" term="%22Cave+DD%22">Cave DD</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy. donatella.dellecave@igb.cnr.it.<br /><searchLink fieldCode="AU" term="%22Di+Domenico+A%22">Di Domenico A</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Fantuz+M%22">Fantuz M</searchLink>; Department of Biology, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Ciotola+M%22">Ciotola M</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Mangini+M%22">Mangini M</searchLink>; Institute of Endotypes in Oncology, Metabolism and Immunology 'G. Salvatore' (IEOMI), Second Unit, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Buonaiuto+S%22">Buonaiuto S</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Corrado+B%22">Corrado B</searchLink>; Interdisciplinary Research Centre on Biomaterials, University of Naples Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Corona+M%22">Corona M</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Saracino+F%22">Saracino F</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Andolfi+G%22">Andolfi G</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Biase+I%22">Di Biase I</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Cucciardi+A%22">Cucciardi A</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Carrer+A%22">Carrer A</searchLink>; Department of Biology, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Sainz+B+Jr%22">Sainz B Jr</searchLink>; Department of Cancer, Instituto de Investigaciones Biomedicas Sols-Morreale (IIBM), CSIC-UAM, Madrid, Spain.; Cancer Area 3-Instituto Ramon Y Cajal de Investigacion Sanitaria (IRYCIS), Madrid, Spain.; Centro de Investigación Biomédica en Red, Área Cáncer, CIBERONC, ISCIII, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pirozzi+T%22">Pirozzi T</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Re+DL%22">Re DL</searchLink>; Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, Universidad de Granada, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Colonna+V%22">Colonna V</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Minchiotti+G%22">Minchiotti G</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22De+Luca+AC%22">De Luca AC</searchLink>; Institute of Endotypes in Oncology, Metabolism and Immunology 'G. Salvatore' (IEOMI), Second Unit, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Lonardo+E%22">Lonardo E</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy. enza.lonardo@igb.cnr.it.
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