Adjuvant nivolumab in muscle-invasive urothelial carcinoma: exploratory biomarker analysis of the randomized phase 3 CheckMate 274 trial.

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Title: Adjuvant nivolumab in muscle-invasive urothelial carcinoma: exploratory biomarker analysis of the randomized phase 3 CheckMate 274 trial.
Authors: Galsky MD; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. matthew.galsky@mssm.edu., Bajorin DF; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tomita Y; Department of Urology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Ye D; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China., Agerbaek M; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Enting D; Department of Oncology, Guy's and St Thomas' NHS Foundation Trust, London, UK., Peer A; Department of Oncology, Rambam Health Care Campus, Haifa, Israel., Milowsky M; Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Kobayashi K; Department of Urology, Sapporo Medical University, Sapporo, Japan., Grimm MO; Department of Urology, Jena University Hospital, Jena, Germany., Stenner F; Department of Oncology, University Hospital Basel, Basel, Switzerland., David JM; Translational Medicine, Bristol Myers Squibb, Princeton, NJ, USA.; Translational Sciences Oncology, BioNTech US, Cambridge, MA, USA., Li J; Translational Bioinformatics, Bristol Myers Squibb, Princeton, NJ, USA., Chasalow SD; Translational Bioinformatics, Bristol Myers Squibb, Princeton, NJ, USA.; Statistics, Metrum Research Group, Boston, MA, USA., Nasroulah F; Department of Clinical Research, Bristol Myers Squibb, Princeton, NJ, USA.; Daiichi Sankyo Inc, Basking Ridge, NJ, USA., Apfel A; Translational Bioinformatics, Bristol Myers Squibb, Princeton, NJ, USA.; Eisai Inc, Nutley, NJ, USA., Ünsal-Kaçmaz K; Translational Medicine, Bristol Myers Squibb, Princeton, NJ, USA.; Translational Sciences Oncology, BioNTech US, Cambridge, MA, USA., Necchi A; Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.
Source: Nature medicine [Nat Med] 2025 Sep; Vol. 31 (9), pp. 3062-3073. Date of Electronic Publication: 2025 Aug 07.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-170X
DOI:10.1038/s41591-025-03802-8