Brain transcriptomics highlight abundant gene expression and splicing alterations in non-neuronal cells in aFTLD-U.

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Title: Brain transcriptomics highlight abundant gene expression and splicing alterations in non-neuronal cells in aFTLD-U.
Authors: Alidadiani S; Department of Biomedical Sciences, University of Antwerp, Building V 0.10, Universiteitsplein 1, 2610, Antwerp, Belgium.; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Faura J; Department of Biomedical Sciences, University of Antwerp, Building V 0.10, Universiteitsplein 1, 2610, Antwerp, Belgium.; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Wynants S; Department of Biomedical Sciences, University of Antwerp, Building V 0.10, Universiteitsplein 1, 2610, Antwerp, Belgium.; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Peeters N; Department of Biomedical Sciences, University of Antwerp, Building V 0.10, Universiteitsplein 1, 2610, Antwerp, Belgium.; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Van den Broeck M; Department of Biomedical Sciences, University of Antwerp, Building V 0.10, Universiteitsplein 1, 2610, Antwerp, Belgium.; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., De Witte L; Department of Biomedical Sciences, University of Antwerp, Building V 0.10, Universiteitsplein 1, 2610, Antwerp, Belgium.; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Policarpo R; Department of Biomedical Sciences, University of Antwerp, Building V 0.10, Universiteitsplein 1, 2610, Antwerp, Belgium.; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Cheung S; Department of Pathology, Vancouver Coastal Health, Vancouver, BC, Canada., Pottier C; Department of Biomedical Sciences, University of Antwerp, Building V 0.10, Universiteitsplein 1, 2610, Antwerp, Belgium.; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Ghayal NB; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Mol MO; Alzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands., van Blitterswijk M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Udine E; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., DeJesus-Hernandez M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Baker M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Finch NA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Asmann YW; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA., van Rooij JGJ; Alzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands., Nguyen AT; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Ross Reichard R; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Nana AL; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Lopez OL; Department of Neurology, University of Pittsburgh, Pittsburg, PA, USA., Boxer AL; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Rosen HJ; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Spina S; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Herms J; Center for Neuropathology and Prion Research, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany., Josephs KA; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Rissman RA; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, CA, USA., Hiniker A; Department of Pathology, University of California San Diego, La Jolla, CA, USA.; Department of Pathology, University of Southern California, Los Angeles, CA, USA., Ang LC; Department of Pathology and Laboratory Medicine, University of Western Ontario, London, ON, Canada.; Department of Pathology, London Health Sciences Center, Western University, London, ON, Canada., Grinberg LT; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Halliday GM; University of Sydney, Sydney, Australia., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Seelaar H; Alzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands., Neumann M; Molecular Neuropathology of Neurodegenerative Diseases, DZNE Tuebingen, Tübingen, Germany.; Department of Neuropathology, University Hospital of Tuebingen, Tübingen, Germany., Kofler J; Department of Pathology, University of Pittsburgh, Pittsburg, PA, USA., White CL 3rd; Division of Neuropathology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Seeley WW; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA., van Swieten JC; Alzheimer Center, Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Mackenzie IRA; Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver General Hospital, Vancouver, BC, Canada., De Coster W; Department of Biomedical Sciences, University of Antwerp, Building V 0.10, Universiteitsplein 1, 2610, Antwerp, Belgium.; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Rademakers R; Department of Biomedical Sciences, University of Antwerp, Building V 0.10, Universiteitsplein 1, 2610, Antwerp, Belgium. rosa.rademakers@uantwerpen.vib.be.; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium. rosa.rademakers@uantwerpen.vib.be.; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. rosa.rademakers@uantwerpen.vib.be.
Source: Acta neuropathologica [Acta Neuropathol] 2025 Aug 10; Vol. 150 (1), pp. 17. Date of Electronic Publication: 2025 Aug 10.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0533
DOI:10.1007/s00401-025-02919-x