Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy.

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Title: Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy.
Authors: Roberts JA; University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Herston, Brisbane, Australia. j.roberts@uq.edu.au.; Herston Infectious Diseases Institute (HeIDI), Metro North Health, Brisbane, Australia. j.roberts@uq.edu.au.; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Australia. j.roberts@uq.edu.au.; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia. j.roberts@uq.edu.au.; Division of Anesthesia Critical Care, Pain and Emergency Medicine, Nîmes University Hospital, UR-UM103 IMAGINE, Universite Montpellier, Montpellier, France. j.roberts@uq.edu.au., Ulldemolins M; University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Herston, Brisbane, Australia., Liu X; University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Herston, Brisbane, Australia., Baptista JP; Intensive Care Medicine Department, Hospitais da Universidade de Coimbra (HUC), ULS Coimbra, Coimbra, Portugal., Bilgrami I; Intensive Care Unit, Royal Darwin Hospital, Tiwi, NT, Australia., Boidin C; University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Herston, Brisbane, Australia.; Laboratoire de Biométrie et Biologie Évolutive, Université Claude Bernard Lyon 1, UMR CNRS 5558, Lyon, France.; Service de Pharmacie, GH Nord, Hospices Civils de Lyon, Lyon, France., Brinkmann A; Department of Anesthesia and Critical Care Medicine, General Hospital of Heidenheim, Heidenheim, Germany., Castro P; Medical Intensive Care Unit, Institut Clínic de Medicina I Dermatologia, Hospital Clínic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Choi G; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong., Cole L; School of Medicine, University of Sydney, Sydney, Australia.; Intensive Care Unit, Nepean Hospital, Sydney, Australia., De Waele JJ; Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Deans R; University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Herston, Brisbane, Australia., Donnellan S; Department of Nephrology, Dunedin Public Hospital, Dunedin, New Zealand., Eastwood GM; Department of Intensive Care, Austin Hospital, Heidelberg, Australia., Frey OR; Department of Pharmacy, General Hospital of Heidenheim, Heidenheim, Germany., Goutelle S; Laboratoire de Biométrie et Biologie Évolutive, Université Claude Bernard Lyon 1, UMR CNRS 5558, Lyon, France.; Service de Pharmacie, GH Nord, Hospices Civils de Lyon, Lyon, France., Gresham R; Intensive Care Unit, Nepean Hospital, Sydney, Australia., Jamal JA; Department of Clinical Pharmacy, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Malaysia., Joynt GM; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong., Kanji S; Department of Pharmacy, The Ottawa Hospital, Ottawa, Canada.; The Ottawa Hospital Research Institute, Ottawa, Canada., Kluge S; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., König C; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hospital Pharmacy, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Koulouras VP; Intensive Care Unit Department, University Hospital of Ioannina, Ioannina, Greece., Lassig-Smith M; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia., Laterre PF; Intensive Care Unit, Clinique Universitaire St Luc, UCLouvain, Brussels, Belgium., Lee A; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong., Lefrant JY; Division of Anesthesia Critical Care, Pain and Emergency Medicine, Nîmes University Hospital, UR-UM103 IMAGINE, Universite Montpellier, Montpellier, France., Lei K; Guy's and St Thomas Hospital, London, UK., Leung P; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong., Llaurado-Serra M; Department of Fundamental and Clinical Care Nursing, Faculty of Nursing, Bellvitge Campus, University of Barcelona, Barcelona, Spain., Martin-Loeches I; Multidisciplinary Intensive Care Research Organization (MICRO), St James Hospital, Dublin, Ireland.; School of Medicine, Trinity College Dublin, Dublin, Ireland., Nor MBM; Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan Campus, Kuantan, Pahang, Malaysia., Mudaliar Y; Critical Care Intensive Care Unit Services, Westmead Public/Private Hospitals, Sydney, Australia., Ostermann M; Guy's and St Thomas Hospital, London, UK., Paul SK; College of Life Sciences, University of Leicester, Leicester, UK., Peake SL; Department of Intensive Care Medicine, The Queen Elizabeth Hospital, Woodville, Australia.; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.; School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia., Rello J; Division of Anesthesia Critical Care, Pain and Emergency Medicine, Nîmes University Hospital, UR-UM103 IMAGINE, Universite Montpellier, Montpellier, France.; Clinical Research in Pneumonia and Sepsis, Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain., Roberts DM; New South Wales Poisons Information Centre, Sydney Children's Hospitals Network, Westmead, Australia.; Edith Collins Centre, Drug Health Services, Royal Prince Alfred Hospital, Camperdown, Australia., Roberts MS; Therapeutics Research Centre, UQCCR and Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; Therapeutics Research Centre, Basil Hetzel Institute for Translational Medical Research, The Queen Elizabeth Hospital, Adelaide, Australia., Richards B; Intensive Care Unit, Gold Coast University Hospital, Gold Coast, Australia., Rodríguez A; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.; Critical Care Department, Hospital Universitari Joan XXIII, Tarragona, Spain.; Faculty of Medicine, Universitat Rovira i Virgili, Tarragona, Spain.; Pere Virgili Health Research Institute, Tarragona, Spain., Roehr AC; Department of Pharmacy, General Hospital of Heidenheim, Heidenheim, Germany., Roger C; Division of Anesthesia Critical Care, Pain and Emergency Medicine, Nîmes University Hospital, UR-UM103 IMAGINE, Universite Montpellier, Montpellier, France., Seoane L; Faculty of Medicine, The University of Queensland, New Orleans, USA.; Intensive Care Unit, Ochsner Health System, New Orleans, USA.; University of Queensland Ochsner Clinical School, New Orleans, USA., Sinnollareddy M; Therapeutics Research Centre, UQCCR and Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Sousa E; Intensive Care Medicine Department, Hospitais da Universidade de Coimbra (HUC), ULS Coimbra, Coimbra, Portugal., Soy D; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.; Pharmacy Department, Division of Medicines, Hospital Clínic de Barcelona, Barcelona, Spain.; Department of Pharmacology, Toxicology and Therapeutic Chemistry-School of Pharmacy, University of Barcelona, Barcelona, Spain., Spring A; Intensive Care Unit, Naval and Veterans Hospital of Athens, Athens, Greece., Starr T; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia., Stephens D; Intensive Care Unit, Royal Darwin Hospital, Tiwi, NT, Australia.; CDU Menzies School of Medicine, Charles Darwin University, Casuarina, Australia.; National Critical Care and Trauma Response Centre, Darwin, Australia., Taccone FS; Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, Belgium., Thomas J; Intensive Care Unit, Royal Darwin Hospital, Tiwi, NT, Australia., Turnidge J; School of Biological Sciences, University of Adelaide, Adelaide, Australia., Valkonen M; Intensive Care Medicine, Department of Perioperative, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Varghese JM; University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Herston, Brisbane, Australia., Wallis SC; University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Herston, Brisbane, Australia., Walker RJ; Department of Nephrology, Dunedin Public Hospital, Dunedin, New Zealand.; Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand., Williams T; Department of Intensive Care Medicine, The Queen Elizabeth Hospital, Woodville, Australia.; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.; School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia., Wilson LC; Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand., Wittebole X; Intensive Care Unit, Clinique Universitaire St Luc, UCLouvain, Brussels, Belgium., Wright DFB; Sydney Pharmacy School, University of Sydney, Sydney, Australia.; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital Sydney, Darlinghurst, Australia.; St Vincent's Clinical Campus, UNSW Medicine, Sydney, Australia., Zikou XT; Intensive Care Unit Department, Army Share Fund Hospital Athens, Athens, Greece., Bellomo R; Department of Intensive Care, Austin Hospital, Heidelberg, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Parkville, Australia.; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Australia.; Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.; Data Analytics Research and Evaluation Centre, Austin Hospital, Melbourne, Australia., Lipman J; University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Herston, Brisbane, Australia.; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.; Division of Anesthesia Critical Care, Pain and Emergency Medicine, Nîmes University Hospital, UR-UM103 IMAGINE, Universite Montpellier, Montpellier, France.; Jamieson Trauma Institute, Royal Brisbane and Women's Hospital, Brisbane, Australia.
Corporate Authors: SMARRT Study Collaborators
Source: Intensive care medicine [Intensive Care Med] 2025 Sep; Vol. 51 (9), pp. 1628-1640. Date of Electronic Publication: 2025 Aug 13.
Publication Type: Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-1238
DOI:10.1007/s00134-025-08067-w