Bezafibrate treatment rescues neurodevelopmental and neurodegenerative defects in 3D cortical organoid model of MAPT frontotemporal dementia.
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| Title: | Bezafibrate treatment rescues neurodevelopmental and neurodegenerative defects in 3D cortical organoid model of MAPT frontotemporal dementia. |
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| Authors: | Cordella F; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy., Mautone L; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy., Salerno D; Department of Molecular Medicine, Sapienza University of Rome, Roma, Italy., Tondo L; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy., Ghirga S; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy., D'Antoni C; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy., Parente E; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy., Romeo MA; Department of Experimental Medicine, Sapienza University of Rome, Roma, Italy., Cirone M; Department of Experimental Medicine, Sapienza University of Rome, Roma, Italy., Bezzi P; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland., Di Angelantonio S; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy.; D-Tails Research srl BC, Rome, Italy. |
| Source: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Aug; Vol. 21 (8), pp. e70419. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1552-5279 |
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| DOI: | 10.1002/alz.70419 |
