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Bezafibrate treatment rescues neurodevelopmental and neurodegenerative defects in 3D cortical organoid model of MAPT frontotemporal dementia.

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Title: Bezafibrate treatment rescues neurodevelopmental and neurodegenerative defects in 3D cortical organoid model of MAPT frontotemporal dementia.
Authors: Cordella F; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy., Mautone L; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy., Salerno D; Department of Molecular Medicine, Sapienza University of Rome, Roma, Italy., Tondo L; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy., Ghirga S; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy., D'Antoni C; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy., Parente E; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy., Romeo MA; Department of Experimental Medicine, Sapienza University of Rome, Roma, Italy., Cirone M; Department of Experimental Medicine, Sapienza University of Rome, Roma, Italy., Bezzi P; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland., Di Angelantonio S; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy.; D-Tails Research srl BC, Rome, Italy.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Aug; Vol. 21 (8), pp. e70419.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Bezafibrate treatment rescues neurodevelopmental and neurodegenerative defects in 3D cortical organoid model of MAPT frontotemporal dementia.
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  Data: <searchLink fieldCode="AU" term="%22Cordella+F%22">Cordella F</searchLink>; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Mautone+L%22">Mautone L</searchLink>; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Salerno+D%22">Salerno D</searchLink>; Department of Molecular Medicine, Sapienza University of Rome, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Tondo+L%22">Tondo L</searchLink>; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Ghirga+S%22">Ghirga S</searchLink>; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22D'Antoni+C%22">D'Antoni C</searchLink>; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Parente+E%22">Parente E</searchLink>; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Romeo+MA%22">Romeo MA</searchLink>; Department of Experimental Medicine, Sapienza University of Rome, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Cirone+M%22">Cirone M</searchLink>; Department of Experimental Medicine, Sapienza University of Rome, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Bezzi+P%22">Bezzi P</searchLink>; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Di+Angelantonio+S%22">Di Angelantonio S</searchLink>; Department of Physiology and Pharmacology 'V. Erspamer' and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, Roma, Italy.; Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy.; D-Tails Research srl BC, Rome, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2025 Aug; Vol. 21 (8), pp. e70419.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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        Value: 10.1002/alz.70419
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              Text: 2025 Aug
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              Y: 2025
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