Associations between epilepsy-related polygenic risk and brain morphology in childhood.

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Title: Associations between epilepsy-related polygenic risk and brain morphology in childhood.
Authors: Ngo A; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3A 1A1., Liu L; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.; Department of Human Genetics, McGill University, Montreal, QC, Canada H3A 1Y2., Larivière S; Department of Medical Imaging and Radiation Sciences, Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4., Kebets V; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3A 1A1., Fett S; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3A 1A1., Weber CF; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.; Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck 23538, Germany.; Centre of Brain, Behavior and Metabolism, University of Lübeck, Lübeck 23562, Germany., Royer J; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3A 1A1., Yu E; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.; Department of Human Genetics, McGill University, Montreal, QC, Canada H3A 1Y2., Rodríguez-Cruces R; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3A 1A1., Zhang Z; Department of Medical Imaging, Nanjing University School of Medicine, Nanjing 211166, China., Ooi LQR; Centre for Sleep and Cognition, National University of Singapore, Singapore 117549  Singapore.; Centre for Translational Magnetic Resonance, National University of Singapore, Singapore 117549, Singapore.; Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore., Yeo BTT; Centre for Sleep and Cognition, National University of Singapore, Singapore 117549  Singapore.; Centre for Translational Magnetic Resonance, National University of Singapore, Singapore 117549, Singapore.; Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore., Frauscher B; Department of Neurology, Duke University, Durham, NC 27710, USA.; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA., Paquola C; Institute of Neuroscience and Medicine (INM-7), Forschungszentrum Jülich, Jülich 52428, Germany., Caligiuri ME; Neuroscience Research Center, University Magna Græcia, Catanzaro 88100, Italy., Gambardella A; Institute of Neurology, University Magna Græcia, Catanzaro 88100, Italy., Concha L; Institute of Neurobiology, Universidad Nacional Autónoma de México, Querétaro 76230, México., Keller SS; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7BE, UK.; Walton Centre NHS Foundation Trust, Liverpool L9 7LJ, UK., Cendes F; Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo 13083887, Brazil., Yasuda CL; Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo 13083887, Brazil., Bonilha L; Department of Neurology, University of South Carolina School of Medicine, Columbia, SC 29202, USA., Gleichgerrcht E; Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA., Focke NKN; Department of Neurology, University of Medicine Göttingen, Göttingen 37075, Germany., Kotikalapudi R; Department of Neurology, University of Medicine Göttingen, Göttingen 37075, Germany., O'Brien TJ; Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Melbourne, VIC 3004, Australia.; Departments of Medicine and Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, VIC 3050, Australia., Sinclair B; Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Melbourne, VIC 3004, Australia.; Departments of Medicine and Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, VIC 3050, Australia., Vivash L; Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Melbourne, VIC 3004, Australia.; Departments of Medicine and Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, VIC 3050, Australia., Desmond PM; Departments of Medicine and Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, VIC 3050, Australia., Lui E; Departments of Medicine and Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, VIC 3050, Australia., Vaudano AE; Neurophysiology Unit and Epilepsy Centre, Azienda Ospedaliera-Universitaria, Modena 41126, Italy.; Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena 41125, Italy., Meletti S; Neurophysiology Unit and Epilepsy Centre, Azienda Ospedaliera-Universitaria, Modena 41126, Italy.; Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena 41125, Italy., Kälviäinen R; Epilepsy Center, Neuro Center, Kuopio University Hospital, Member of the European Reference Network for Rare and Complex Epilepsies EpiCARE, Kuopio 70210, Finland.; Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio 70210, Finland., Soltanian-Zadeh H; Control and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, University of Tehran, Tehran 1439957131, Iran.; Departments of Research Administration and Radiology, Henry Ford Health System, Detroit 48202, USA., Winston GP; Division of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada K7L 2V7.; Department of Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.; Chalfont Centre for Epilepsy, Epilepsy Society, Bucks SL9 0RJ, UK., Tiwari VK; Institute for Molecular Medicine, University of Southern Denmark, Odense s5230, Denmark., Kreilkamp BAK; Department of Neurology, University of Medicine Göttingen, Göttingen 37075, Germany., Lenge M; Neuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence 50139, Italy., Guerrini R; Neuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence 50139, Italy.; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence 50121, Italy., Hamandi K; The Wales Epilepsy Unit, Department of Neurology, University Hospital of Whales, Cardiff CF14 4XW, UK.; Cardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical Sciences, Cardiff University, Cardiff CF24 4HQ, UK., Rüber T; Department of Epileptology, University Hospital Bonn, Bonn 53127, Germany.; Department of Neuroradiology, University Hospital Bonn, Bonn 53127, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany.; Center for Medical Data Usability and Translation, University of Bonn, Bonn 53113, Germany., Bauer T; Department of Epileptology, University Hospital Bonn, Bonn 53127, Germany.; Department of Neuroradiology, University Hospital Bonn, Bonn 53127, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany., Devinsky O; Department of Neurology, NYU Grossman School of Medicine, New York, NY 10017, USA., Striano P; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova 16147, Italy.; IRCCS Instituto Giannina Gaslini, full member of ERN EpiCare, Genova 16147, Italy., Kaestner E; Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA 92093, USA., Hatton SN; Department of Neurosciences, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA 92093, USA., Caciagli L; Division of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada K7L 2V7.; Department of Neurology, Inselspital, Sleep-Wake-Epilepsy-Center, Bern University Hospital, University of Bern, Bern 3010, Switzerland., Kirschner M; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital University of Zurich, Zurich 8008, Switzerland.; Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva 1205, Switzerland., Duncan JS; Division of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada K7L 2V7.; Department of Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Thompson PM; Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., McDonald CR; Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA 92093, USA.; Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA 92093, USA., Sisodiya SM; Division of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada K7L 2V7.; Department of Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Bernasconi N; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3A 1A1., Bernasconi A; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3A 1A1., Gan-Or Z; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3A 1A1.; Department of Human Genetics, McGill University, Montreal, QC, Canada H3A 1Y2., Bernhardt BC; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3A 1A1.
Corporate Authors: ENIGMA Consortium Epilepsy Working Group
Source: Brain : a journal of neurology [Brain] 2026 Feb 07; Vol. 149 (2), pp. 519-533.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1460-2156
DOI:10.1093/brain/awaf259