Covalently constrained 'Di-Gembodies' enable parallel structure solutions by cryo-EM.

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Bibliographic Details
Title: Covalently constrained 'Di-Gembodies' enable parallel structure solutions by cryo-EM.
Authors: Yi G; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, UK.; Calleva Centre for Evolution and Human Science, Magdalen College, Oxford, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK., Mamalis D; Department of Chemistry, University of Oxford, Oxford, UK.; The Rosalind Franklin Institute, Oxfordshire, UK., Ye M; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK. martin.ye@cmd.ox.ac.uk., Carrique L; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, UK., Fairhead M; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK., Li H; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK., Duerr KL; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK.; Mass Therapeutics, Ltd., Oxford, UK., Zhang P; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK., Sauer DB; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK. david.sauer@cmd.ox.ac.uk., von Delft F; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK. frank.vondelft@cmd.ox.ac.uk.; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK. frank.vondelft@cmd.ox.ac.uk.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK. frank.vondelft@cmd.ox.ac.uk.; Department of Biochemistry, University of Johannesburg, Auckland Park, Johannesburg, South Africa. frank.vondelft@cmd.ox.ac.uk., Davis BG; Department of Chemistry, University of Oxford, Oxford, UK. ben.davis@rfi.ac.uk.; The Rosalind Franklin Institute, Oxfordshire, UK. ben.davis@rfi.ac.uk.; Department of Pharmacology, University of Oxford, Oxford, UK. ben.davis@rfi.ac.uk., Gilbert RJC; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, UK. robert.gilbert@magd.ox.ac.uk.; Calleva Centre for Evolution and Human Science, Magdalen College, Oxford, UK. robert.gilbert@magd.ox.ac.uk.
Source: Nature chemical biology [Nat Chem Biol] 2026 Jan; Vol. 22 (1), pp. 69-76. Date of Electronic Publication: 2025 Aug 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1552-4469
DOI:10.1038/s41589-025-01972-7