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Covalently constrained 'Di-Gembodies' enable parallel structure solutions by cryo-EM.

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Title: Covalently constrained 'Di-Gembodies' enable parallel structure solutions by cryo-EM.
Authors: Yi G; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, UK.; Calleva Centre for Evolution and Human Science, Magdalen College, Oxford, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK., Mamalis D; Department of Chemistry, University of Oxford, Oxford, UK.; The Rosalind Franklin Institute, Oxfordshire, UK., Ye M; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK. martin.ye@cmd.ox.ac.uk., Carrique L; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, UK., Fairhead M; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK., Li H; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK., Duerr KL; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK.; Mass Therapeutics, Ltd., Oxford, UK., Zhang P; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK., Sauer DB; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK. david.sauer@cmd.ox.ac.uk., von Delft F; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK. frank.vondelft@cmd.ox.ac.uk.; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK. frank.vondelft@cmd.ox.ac.uk.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK. frank.vondelft@cmd.ox.ac.uk.; Department of Biochemistry, University of Johannesburg, Auckland Park, Johannesburg, South Africa. frank.vondelft@cmd.ox.ac.uk., Davis BG; Department of Chemistry, University of Oxford, Oxford, UK. ben.davis@rfi.ac.uk.; The Rosalind Franklin Institute, Oxfordshire, UK. ben.davis@rfi.ac.uk.; Department of Pharmacology, University of Oxford, Oxford, UK. ben.davis@rfi.ac.uk., Gilbert RJC; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, UK. robert.gilbert@magd.ox.ac.uk.; Calleva Centre for Evolution and Human Science, Magdalen College, Oxford, UK. robert.gilbert@magd.ox.ac.uk.
Source: Nature chemical biology [Nat Chem Biol] 2026 Jan; Vol. 22 (1), pp. 69-76. Date of Electronic Publication: 2025 Aug 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Yi+G%22">Yi G</searchLink>; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, UK.; Calleva Centre for Evolution and Human Science, Magdalen College, Oxford, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.<br /><searchLink fieldCode="AU" term="%22Mamalis+D%22">Mamalis D</searchLink>; Department of Chemistry, University of Oxford, Oxford, UK.; The Rosalind Franklin Institute, Oxfordshire, UK.<br /><searchLink fieldCode="AU" term="%22Ye+M%22">Ye M</searchLink>; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK. martin.ye@cmd.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Carrique+L%22">Carrique L</searchLink>; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Fairhead+M%22">Fairhead M</searchLink>; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Duerr+KL%22">Duerr KL</searchLink>; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK.; Mass Therapeutics, Ltd., Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Sauer+DB%22">Sauer DB</searchLink>; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK. david.sauer@cmd.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22von+Delft+F%22">von Delft F</searchLink>; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK. frank.vondelft@cmd.ox.ac.uk.; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Oxford, UK. frank.vondelft@cmd.ox.ac.uk.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK. frank.vondelft@cmd.ox.ac.uk.; Department of Biochemistry, University of Johannesburg, Auckland Park, Johannesburg, South Africa. frank.vondelft@cmd.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Davis+BG%22">Davis BG</searchLink>; Department of Chemistry, University of Oxford, Oxford, UK. ben.davis@rfi.ac.uk.; The Rosalind Franklin Institute, Oxfordshire, UK. ben.davis@rfi.ac.uk.; Department of Pharmacology, University of Oxford, Oxford, UK. ben.davis@rfi.ac.uk.<br /><searchLink fieldCode="AU" term="%22Gilbert+RJC%22">Gilbert RJC</searchLink>; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, UK. robert.gilbert@magd.ox.ac.uk.; Calleva Centre for Evolution and Human Science, Magdalen College, Oxford, UK. robert.gilbert@magd.ox.ac.uk.
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