Alpha-ketoglutarate modulates the reprogramming of mitochondrial and nuclear DNA methylation during the earliest stages of the bovine preimplantation embryo development†.

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Title: Alpha-ketoglutarate modulates the reprogramming of mitochondrial and nuclear DNA methylation during the earliest stages of the bovine preimplantation embryo development†.
Authors: Ispada J; Laboratory of Embryonic Metabolism and Epigenetics, Centre of Natural and Human Science, Federal University of ABC, Santo Andre, SP, Brazil., de Lima CB; Laboratory of Embryonic Metabolism and Epigenetics, Centre of Natural and Human Science, Federal University of ABC, Santo Andre, SP, Brazil.; Centre de Recherche en Reproduction, Développement et Santé Intergénérationnelle (CRDSI), Département des Sciences Animales, Université Laval, Québec, QC, Canada., da Fonseca-Junior AM; Laboratory of Embryonic Metabolism and Epigenetics, Centre of Natural and Human Science, Federal University of ABC, Santo Andre, SP, Brazil., Dos Santos EC; Laboratory of Embryonic Metabolism and Epigenetics, Centre of Natural and Human Science, Federal University of ABC, Santo Andre, SP, Brazil., Martin H; Centre de Recherche en Reproduction, Développement et Santé Intergénérationnelle (CRDSI), Département des Sciences Animales, Université Laval, Québec, QC, Canada., Ross PJ; STGenetics, Navasota, TX, United States of America., Sirard MA; Centre de Recherche en Reproduction, Développement et Santé Intergénérationnelle (CRDSI), Département des Sciences Animales, Université Laval, Québec, QC, Canada., Milazzotto MP; Laboratory of Embryonic Metabolism and Epigenetics, Centre of Natural and Human Science, Federal University of ABC, Santo Andre, SP, Brazil.
Source: Biology of reproduction [Biol Reprod] 2025 Sep 15; Vol. 113 (3), pp. 527-540.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0207224 Publication Model: Print Cited Medium: Internet ISSN: 1529-7268 (Electronic) Linking ISSN: 00063363 NLM ISO Abbreviation: Biol Reprod Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1529-7268
DOI:10.1093/biolre/ioaf119