iPSC-modelling reveals genetic associations and morphological alterations of oligodendrocytes in schizophrenia.

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Title: iPSC-modelling reveals genetic associations and morphological alterations of oligodendrocytes in schizophrenia.
Authors: Chang MH; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany.; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), 80804, Munich, Germany., Waldeck JB; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany., Stephan M; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany.; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), 80804, Munich, Germany.; Systasy Bioscience GmbH, 81669, Munich, Germany., Kannaiyan N; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany.; Systasy Bioscience GmbH, 81669, Munich, Germany., de Almeida V; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany.; Department of Psychiatry, University of Münster, 48149, Münster, Germany.; Center for Soft Nanoscience, University of Münster, 48149, Münster, Germany., Boudriot E; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany.; Max Planck Institute of Psychiatry, 80804, Munich, Germany., Karali T; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany.; NeuroImaging Core Unit Munich (NICUM), LMU University Hospital, LMU Munich, 80336, Munich, Germany., Röll L; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany.; Max Planck Institute of Psychiatry, 80804, Munich, Germany.; NeuroImaging Core Unit Munich (NICUM), LMU University Hospital, LMU Munich, 80336, Munich, Germany., Fischer L; Max Planck Institute of Psychiatry, 80804, Munich, Germany., Demetriou D; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany., Gabellini N; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany., Galinski S; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany.; Systasy Bioscience GmbH, 81669, Munich, Germany., Schmitt A; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany.; German Center for Mental Health (DZPG), partner site Munich/Augsburg, Munich, Germany.; Laboratory of Neurosciences (LIM-27), Institute of Psychiatry, University of São Paulo (USP), São Paulo-SP, 05403-903, Brazil., Papiol S; Max Planck Institute of Psychiatry, 80804, Munich, Germany.; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, 80336, Munich, Germany., Keeser D; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany.; NeuroImaging Core Unit Munich (NICUM), LMU University Hospital, LMU Munich, 80336, Munich, Germany.; Munich Center for Neurosciences (MCN), LMU Munich, 82152, Planegg-Martinsried, Germany., Falkai P; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany.; Max Planck Institute of Psychiatry, 80804, Munich, Germany.; German Center for Mental Health (DZPG), partner site Munich/Augsburg, Munich, Germany., Rossner MJ; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany. moritz.rossner@med.uni-muenchen.de.; Systasy Bioscience GmbH, 81669, Munich, Germany. moritz.rossner@med.uni-muenchen.de., Raabe FJ; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, 80336, Munich, Germany. florian_raabe@psych.mpg.de.; Max Planck Institute of Psychiatry, 80804, Munich, Germany. florian_raabe@psych.mpg.de.
Source: Translational psychiatry [Transl Psychiatry] 2025 Aug 16; Vol. 15 (1), pp. 287. Date of Electronic Publication: 2025 Aug 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2158-3188
DOI:10.1038/s41398-025-03509-x