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Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa.

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Title: Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa.
Authors: Eisenhauer J; Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, United States.; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States., Dublin S; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States., Choi J; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States., Trachtman AR; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States., Chu JD; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States., Custodio-Zegarra D; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States., Bharti S; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States., Bhardwaj B; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States., Bai S; Paul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, WA, United States., Witt WT; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States., Gutierrez MP; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States., Miller SJ; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States., Flowers K; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States., Smith TRF; Inovio Pharmaceuticals, Plymouth Meeting, PA, United States., Gunn BM; Paul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, WA, United States., Barbier M; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States., Parzych EM; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States., Weiner DB; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States., Patel A; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States.
Source: Frontiers in immunology [Front Immunol] 2025 Jul 31; Vol. 16, pp. 1618297. Date of Electronic Publication: 2025 Jul 31 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa.
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  Data: <searchLink fieldCode="AU" term="%22Eisenhauer+J%22">Eisenhauer J</searchLink>; Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, United States.; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Dublin+S%22">Dublin S</searchLink>; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.<br /><searchLink fieldCode="AU" term="%22Choi+J%22">Choi J</searchLink>; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Trachtman+AR%22">Trachtman AR</searchLink>; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Chu+JD%22">Chu JD</searchLink>; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Custodio-Zegarra+D%22">Custodio-Zegarra D</searchLink>; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Bharti+S%22">Bharti S</searchLink>; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Bhardwaj+B%22">Bhardwaj B</searchLink>; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Bai+S%22">Bai S</searchLink>; Paul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, WA, United States.<br /><searchLink fieldCode="AU" term="%22Witt+WT%22">Witt WT</searchLink>; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.<br /><searchLink fieldCode="AU" term="%22Gutierrez+MP%22">Gutierrez MP</searchLink>; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.<br /><searchLink fieldCode="AU" term="%22Miller+SJ%22">Miller SJ</searchLink>; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.<br /><searchLink fieldCode="AU" term="%22Flowers+K%22">Flowers K</searchLink>; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Smith+TRF%22">Smith TRF</searchLink>; Inovio Pharmaceuticals, Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Gunn+BM%22">Gunn BM</searchLink>; Paul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, WA, United States.<br /><searchLink fieldCode="AU" term="%22Barbier+M%22">Barbier M</searchLink>; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.<br /><searchLink fieldCode="AU" term="%22Parzych+EM%22">Parzych EM</searchLink>; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Weiner+DB%22">Weiner DB</searchLink>; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Patel+A%22">Patel A</searchLink>; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, United States.
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