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Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques.

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Title: Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques.
Authors: de Weerd L; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. lis.deweerd@dzne.de., Hummel S; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany., Müller SA; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine and Health, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany., Paris I; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Sandmann T; Denali Therapeutics, Inc, South San Francisco, USA., Eichholtz M; Biochemistry Master's Program, Gene Center Munich, Ludwig-Maximilians University (LMU), Munich, Germany., Gröger R; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany., Englert AL; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany., Wagner S; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany., Ha C; Denali Therapeutics, Inc, South San Francisco, USA., Davis SS; Denali Therapeutics, Inc, South San Francisco, USA., Warkins V; Denali Therapeutics, Inc, South San Francisco, USA., Xia D; Denali Therapeutics, Inc, South San Francisco, USA., Nuscher B; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig- Maximilians University (LMU), Munich, Germany., Berghofer A; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Reich M; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Feiten AF; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig- Maximilians University (LMU), Munich, Germany., Schlepckow K; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Willem M; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig- Maximilians University (LMU), Munich, Germany., Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Neuroproteomics, School of Medicine and Health, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany., Lewcock JW; Denali Therapeutics, Inc, South San Francisco, USA., Monroe KM; Denali Therapeutics, Inc, South San Francisco, USA., Brendel M; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Haass C; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. christian.haass@mail03.med.uni-muenchen.de.; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig- Maximilians University (LMU), Munich, Germany. christian.haass@mail03.med.uni-muenchen.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. christian.haass@mail03.med.uni-muenchen.de.
Source: Molecular neurodegeneration [Mol Neurodegener] 2025 Aug 20; Vol. 20 (1), pp. 92. Date of Electronic Publication: 2025 Aug 20.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1750-1326
DOI:10.1186/s13024-025-00878-1