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Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics.

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Title: Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics.
Authors: Steger M; NEOsphere Biotechnologies GmbH, Martinsried, Germany., Nishiguchi G; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Wu Q; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA., Schwalb B; NEOsphere Biotechnologies GmbH, Martinsried, Germany., Shashikadze B; NEOsphere Biotechnologies GmbH, Martinsried, Germany., McGowan K; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Actis M; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Aggarwal A; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Shi Z; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Price J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Mayasundari A; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Yang L; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Bednarz AH; NEOsphere Biotechnologies GmbH, Martinsried, Germany., Machata S; NEOsphere Biotechnologies GmbH, Martinsried, Germany., Graef T; NEOsphere Biotechnologies GmbH, Martinsried, Germany., Bartoschek D; NEOsphere Biotechnologies GmbH, Martinsried, Germany., Demichev V; Department of Biochemistry, Charité - Universitätsmedizin Berlin, Berlin, Germany., Ohmayer U; NEOsphere Biotechnologies GmbH, Martinsried, Germany., Yang J; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA. jun.yang2@stjude.org.; Department of Pathology and Laboratory Medicine, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA. jun.yang2@stjude.org.; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA. jun.yang2@stjude.org., Daub H; NEOsphere Biotechnologies GmbH, Martinsried, Germany. henrik.daub@neospherebiotech.com., Rankovic Z; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA. zoran.rankovic@icr.ac.uk.; Centre for Protein Degradation, The Institute of Cancer Research, London, UK. zoran.rankovic@icr.ac.uk.
Source: Nature communications [Nat Commun] 2025 Aug 20; Vol. 16 (1), pp. 7773. Date of Electronic Publication: 2025 Aug 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics.
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  Data: <searchLink fieldCode="AU" term="%22Steger+M%22">Steger M</searchLink>; NEOsphere Biotechnologies GmbH, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Nishiguchi+G%22">Nishiguchi G</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Q%22">Wu Q</searchLink>; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Schwalb+B%22">Schwalb B</searchLink>; NEOsphere Biotechnologies GmbH, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Shashikadze+B%22">Shashikadze B</searchLink>; NEOsphere Biotechnologies GmbH, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22McGowan+K%22">McGowan K</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Actis+M%22">Actis M</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Aggarwal+A%22">Aggarwal A</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Shi+Z%22">Shi Z</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Price+J%22">Price J</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Mayasundari+A%22">Mayasundari A</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Bednarz+AH%22">Bednarz AH</searchLink>; NEOsphere Biotechnologies GmbH, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Machata+S%22">Machata S</searchLink>; NEOsphere Biotechnologies GmbH, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Graef+T%22">Graef T</searchLink>; NEOsphere Biotechnologies GmbH, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Bartoschek+D%22">Bartoschek D</searchLink>; NEOsphere Biotechnologies GmbH, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Demichev+V%22">Demichev V</searchLink>; Department of Biochemistry, Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ohmayer+U%22">Ohmayer U</searchLink>; NEOsphere Biotechnologies GmbH, Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA. jun.yang2@stjude.org.; Department of Pathology and Laboratory Medicine, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA. jun.yang2@stjude.org.; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA. jun.yang2@stjude.org.<br /><searchLink fieldCode="AU" term="%22Daub+H%22">Daub H</searchLink>; NEOsphere Biotechnologies GmbH, Martinsried, Germany. henrik.daub@neospherebiotech.com.<br /><searchLink fieldCode="AU" term="%22Rankovic+Z%22">Rankovic Z</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA. zoran.rankovic@icr.ac.uk.; Centre for Protein Degradation, The Institute of Cancer Research, London, UK. zoran.rankovic@icr.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Aug 20; Vol. 16 (1), pp. 7773. <i>Date of Electronic Publication: </i>2025 Aug 20.
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