Toripalimab Combination Therapy Without Concurrent Cisplatin for Nasopharyngeal Carcinoma: The DIAMOND Randomized Clinical Trial.
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| Title: | Toripalimab Combination Therapy Without Concurrent Cisplatin for Nasopharyngeal Carcinoma: The DIAMOND Randomized Clinical Trial. |
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| Authors: | Xu C; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Liang XY; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Huang XQ; Department of Radiation Oncology, Xiangya Hospital of Central South University, Changsha, Hunan, PR China., Jin F; Department of Oncology, Affiliated Hospital of Guizhou Medical University, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, PR China., Yang KY; Institute of Radiation Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Precision Radiation Oncology, Wuhan, Hubei, PR China., Hu GY; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China., Zhu XD; Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Guangxi Key Laboratory of Early Prevention and Treatment for Regional High-Incidence-Tumor, Nanning, Guangxi, PR China., Wang Y; Radiation Oncology Center, Chongqing University Cancer Hospital, Chongqing, PR China., Huang Y; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Zhang N; Department of Nasopharyngeal Oncology, First People's Hospital of Foshan, Foshan, Guangdong, PR China., Hu DS; Department of Radiation Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China., Guo L; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China., Zou GR; Department of Oncology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Panyu Institute of Oncology, Guangzhou, Guangdong, PR China., Chen XZ; Department of Head and Neck Radiotherapy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, Zhejiang, PR China., Xiao SW; Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing, PR China., Li JG; Department of Radiation Oncology, Jiangxi Cancer Hospital & Institute, Second Affiliated Hospital of Nanchang Medical College, NHC Key Laboratory of Personalized Diagnosis and Treatment for Nasopharyngeal Carcinoma, Nanchang, Jiangxi, PR China., Shen LF; Department of Radiation Oncology, Xiangya Hospital of Central South University, Changsha, Hunan, PR China., Li YY; Department of Oncology, Affiliated Hospital of Guizhou Medical University, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, PR China., Huang J; Institute of Radiation Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Precision Radiation Oncology, Wuhan, Hubei, PR China., Long GX; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China., Li L; Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Guangxi Key Laboratory of Early Prevention and Treatment for Regional High-Incidence-Tumor, Nanning, Guangxi, PR China., Huang L; Radiation Oncology Center, Chongqing University Cancer Hospital, Chongqing, PR China., She LJ; Department of Nasopharyngeal Oncology, First People's Hospital of Foshan, Foshan, Guangdong, PR China., Wu Y; Department of Radiation Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China., Zeng WH; Department of Oncology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Panyu Institute of Oncology, Guangzhou, Guangdong, PR China., Qiang MY; Department of Head and Neck Radiotherapy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, Zhejiang, PR China., Liu WX; Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing, PR China., Su Y; Department of Radiation Oncology, Jiangxi Cancer Hospital & Institute, Second Affiliated Hospital of Nanchang Medical College, NHC Key Laboratory of Personalized Diagnosis and Treatment for Nasopharyngeal Carcinoma, Nanchang, Jiangxi, PR China., Tang LL; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Xie FY; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Han F; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Lu LX; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Xiang YQ; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China., Mao YP; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Li WF; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Liu X; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Yang Q; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China., Zhou GQ; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Guo R; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Ouyang PY; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Wang XH; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Chen L; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Liu LT; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China., Lin L; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Li JB; Clinical Trials Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China., Lin AH; Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, PR China., Zhao HY; Departments of Medical Oncology and Clinical Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China., Hong SB; Department of Endocrinology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, PR China., Jie YS; Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, PR China., Huang HL; Department of Cardiology, Cardiac Prevention and Assessment Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, PR China., Tang XH; Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, PR China., Zeng YC; Department of Radiation Oncology, Cancer Treatment Center, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, PR China., Yun JP; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China., Zang SB; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China., Du ZM; Department of Molecular Diagnosis, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China., Ye ZL; Department of Molecular Diagnosis, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China., Liu LZ; Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China., Tian L; Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China., Li HJ; Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China., Peng YL; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Liu N; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Li YQ; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Liang YL; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Wei HM; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Chen YP; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Zhang Y; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Du XJ; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Lv JW; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China., Sun Y; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China.; Chinese Society of Clinical Oncology, Beijing, PR China., Ma J; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, People's Republic (PR) of China.; Chinese Society of Clinical Oncology, Beijing, PR China. |
| Corporate Authors: | DIAMOND Study Group |
| Source: | JAMA [JAMA] 2025 Sep 16; Vol. 334 (11), pp. 973-983. |
| Publication Type: | Clinical Trial, Phase III; Equivalence Trial; Journal Article; Multicenter Study |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1538-3598 |
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| DOI: | 10.1001/jama.2025.13205 |
