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Personalized circulating tumor DNA dynamics inform survival and response to immune checkpoint blockade in recurrent/metastatic head and neck cancer.

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Title: Personalized circulating tumor DNA dynamics inform survival and response to immune checkpoint blockade in recurrent/metastatic head and neck cancer.
Authors: Ruiz-Torres DA; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Merkin RD; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Head and Neck Cancers, Massachusetts General Hospital, Boston, MA, USA., Bryan ME; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mendel J; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA., Efthymiou V; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA., Roberts T; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Head and Neck Cancers, Massachusetts General Hospital, Boston, MA, USA., Patel MJ; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Head and Neck Cancers, Massachusetts General Hospital, Boston, MA, USA., Park JC; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Head and Neck Cancers, Massachusetts General Hospital, Boston, MA, USA., Chevalier A; NeoGenomics, Inc., Fort Meyers, FL, USA., Murray C; NeoGenomics, Inc., Fort Meyers, FL, USA., Gates L; NeoGenomics, Inc., Fort Meyers, FL, USA., Pipinikas C; NeoGenomics, Inc., Fort Meyers, FL, USA., Stott SL; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Engineering in Medicine & Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Fisch AS; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Wirth LJ; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Head and Neck Cancers, Massachusetts General Hospital, Boston, MA, USA., Faden DL; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA. dfaden@mgb.org.; Department of Medicine, Harvard Medical School, Boston, MA, USA. dfaden@mgb.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. dfaden@mgb.org.; Center for Head and Neck Cancers, Massachusetts General Hospital, Boston, MA, USA. dfaden@mgb.org.
Source: NPJ precision oncology [NPJ Precis Oncol] 2025 Aug 22; Vol. 9 (1), pp. 298. Date of Electronic Publication: 2025 Aug 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Personalized circulating tumor DNA dynamics inform survival and response to immune checkpoint blockade in recurrent/metastatic head and neck cancer.
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  Data: <searchLink fieldCode="AU" term="%22Ruiz-Torres+DA%22">Ruiz-Torres DA</searchLink>; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Merkin+RD%22">Merkin RD</searchLink>; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Head and Neck Cancers, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bryan+ME%22">Bryan ME</searchLink>; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mendel+J%22">Mendel J</searchLink>; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Efthymiou+V%22">Efthymiou V</searchLink>; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+T%22">Roberts T</searchLink>; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Head and Neck Cancers, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Patel+MJ%22">Patel MJ</searchLink>; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Head and Neck Cancers, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Park+JC%22">Park JC</searchLink>; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Head and Neck Cancers, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chevalier+A%22">Chevalier A</searchLink>; NeoGenomics, Inc., Fort Meyers, FL, USA.<br /><searchLink fieldCode="AU" term="%22Murray+C%22">Murray C</searchLink>; NeoGenomics, Inc., Fort Meyers, FL, USA.<br /><searchLink fieldCode="AU" term="%22Gates+L%22">Gates L</searchLink>; NeoGenomics, Inc., Fort Meyers, FL, USA.<br /><searchLink fieldCode="AU" term="%22Pipinikas+C%22">Pipinikas C</searchLink>; NeoGenomics, Inc., Fort Meyers, FL, USA.<br /><searchLink fieldCode="AU" term="%22Stott+SL%22">Stott SL</searchLink>; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Engineering in Medicine & Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fisch+AS%22">Fisch AS</searchLink>; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wirth+LJ%22">Wirth LJ</searchLink>; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Head and Neck Cancers, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Faden+DL%22">Faden DL</searchLink>; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA. dfaden@mgb.org.; Department of Medicine, Harvard Medical School, Boston, MA, USA. dfaden@mgb.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. dfaden@mgb.org.; Center for Head and Neck Cancers, Massachusetts General Hospital, Boston, MA, USA. dfaden@mgb.org.
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