Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene.

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Title: Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene.
Authors: Sonehara K; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. Electronic address: qsonehara@m.u-tokyo.ac.jp., Watanabe R; Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Integrative Medicine for Allergic and Immunological Diseases, Osaka University Graduate School of Medicine, Suita, Japan; Department of Dermatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan., Matsumura Y; Department of Dermatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan; Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan., Mitsui Y; Department of Immunology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Ogawa Y; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan; Department of Pediatrics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan., Odomari K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan., Sakaue S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Namba S; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Komuro M; Department of Immunology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Edamoto M; Department of Immunology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Watanabe J; Department of Immunology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Hirota T; Division of Molecular Genetics, Research Center for Medical Science, The Jikei University School of Medicine, Tokyo, Japan., Arase N; Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan., Nakamura Y; Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan; Cutaneous Immunology, Immunology Frontier Research Center, Osaka University, Suita, Japan., Nakajima K; Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan., Okamoto T; Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan., Nishikawa R; Division of Dermatology, Department of Internal Related, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan., Yamamoto K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan; Division of Health Science, Osaka University Graduate School of Medicine, Suita, Japan., Suzuki K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan., Kishikawa T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Japan; Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan., Edahiro R; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan., Shirai Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan., Naito T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Sasa N; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Japan., Ishitsuka Y; Department of Integrative Medicine for Allergic and Immunological Diseases, Osaka University Graduate School of Medicine, Suita, Japan; Department of Dermatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan., Furuta J; Department of Dermatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan., Kunimoto K; Department of Dermatology, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan., Kajihara I; Department of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan., Fukushima S; Department of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan., Miyachi H; Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan., Matsue H; Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan., Kamata M; Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan., Momose M; Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan., Miyagawa I; The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Tanaka H; The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Ueno M; The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Bito T; Division of Dermatology, Department of Internal Related, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan., Nagai H; Division of Dermatology, Department of Internal Related, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan., Ikeda T; Department of Dermatology, Kobe City Hospital Organization Kobe Medical Center West Hospital, Kobe, Japan., Horikawa T; Department of Dermatology, Nishikobe Medical Center, Kobe, Japan., Adachi A; Department of Dermatology, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan., Matsubara T; Matsubara Mayflower Hospital, Kato, Japan., Nishida E; Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Matsuda K; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Tokyo, Japan., Shojima N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan., Nakagawa I; Hokkaido Medical Center for Rheumatic Diseases, Sapporo, Japan., Asano Y; Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan., Sato S; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan., Imafuku S; Department of Dermatology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan., Tada Y; Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan., Nishigori C; Division of Dermatology, Department of Internal Related, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan., Jinnin M; Department of Dermatology, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan., Ihn H; Department of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan., Asahina A; Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan., Saeki H; Department of Dermatology, Nippon Medical School, Tokyo, Japan., Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan; Toranomon Hospital, Tokyo, Japan., Kawamura T; Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan., Shimada S; Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan., Katayama I; Department of Dermatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan; Department of Pigmentation Research and Therapeutics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan., Higasa K; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Genome Analysis, Institute of Biomedical Science, Kansai Medical University, Hirakata, Japan., Noguchi E; Department of Medical Genetics, University of Tsukuba, Tsukuba, Japan., Sano S; Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan., Tanaka Y; The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Matsuda F; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kumanogoh A; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan; Department of Immunopathology, Immunology Frontier Research Center, Osaka University, Suita, Japan., Tamari M; Division of Molecular Genetics, Research Center for Medical Science, The Jikei University School of Medicine, Tokyo, Japan., Satoh T; Department of Immunology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Fujimoto M; Department of Dermatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan; Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan., Morita A; Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Okada Y; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan; Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University, Suita, Japan. Electronic address: yuki-okada@m.u-tokyo.ac.jp.
Corporate Authors: Biobank Japan Project
Source: Cell genomics [Cell Genom] 2025 Oct 08; Vol. 5 (10), pp. 100978. Date of Electronic Publication: 2025 Aug 22.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-979X
DOI:10.1016/j.xgen.2025.100978