A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy.

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Title: A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy.
Authors: Weis AM; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Bauer KM; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Tang WW; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Stephen-Victor E; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Bell R; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Brown DG; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Ekiz HA; Department of Molecular Biology and Genetics, Izmir Institute of Technology, Gulbahce, Urla, Izmir 35430, Turkey., Tran V; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Klag KA; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Swanson EA; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA; Department of Pathology, Scripps Clinic Medical Group, La Jolla, CA, USA., Barrios L; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Harwood M; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Hill JH; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Ost KS; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA; University of Colorado Anschutz School of Medicine, Department of Immunology and Microbiology, Aurora, CO, USA., Gigic B; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Heidelberg, Germany., Schneider M; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Heidelberg, Germany., Ose J; Department of Population Health Science, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Hardikar S; Department of Population Health Science, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Toriola AT; Division of Public Health Sciences, Department of Surgery, Siteman Cancer Center Washington University School of Medicine, St. Louis, MO, USA., Shibata D; Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA., Li CI; Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA., Figueiredo JC; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Byrd DA; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Siegel EM; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Arnolds K; University of Colorado Anschutz School of Medicine, Department of Biomedical Informatics, Aurora, CO, USA., Lozupone C; University of Colorado Anschutz School of Medicine, Department of Biomedical Informatics, Aurora, CO, USA., Ulrich CM; Department of Population Health Science, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., O'Connell RM; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Stephens WZ; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Round JL; Division of Microbiology and Immunology, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address: june.round@path.utah.edu.
Source: Cell reports [Cell Rep] 2025 Sep 23; Vol. 44 (9), pp. 116172. Date of Electronic Publication: 2025 Aug 23.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2025.116172