Multi-population genome-wide association study identifies multiple novel loci associated with asymptomatic intracranial large artery stenosis.

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Title: Multi-population genome-wide association study identifies multiple novel loci associated with asymptomatic intracranial large artery stenosis.
Authors: Liu M; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Khasiyev F; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, University of Minnesota, Minneapolis, MN, USA., Spagnolo-Allende A; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Sanchez DL; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; The Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Andrews H; Biostatistics Department, Mailman School of Public Health, Columbia University, New York, NY, USA., Yang Q; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA., Beiser A; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA., Qiao Y; Johns Hopkins University School of Medicine, Baltimore, MD, USA., Romero JR; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Rundek T; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.; Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA., Brickman AM; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; The Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Manly JJ; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; The Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Elkind MS; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA., Seshadri S; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Chen C; Memory Aging and Cognition Center, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Del Brutto OH; School of Medicine and Research Center, Universidad Espíritu Santo, Samborondón, Ecuador., Hilal S; Memory Aging and Cognition Center, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Wasserman BA; Johns Hopkins University School of Medicine, Baltimore, MD, USA.; University of Maryland School of Medicine, Baltimore, MD, USA., Tosto G; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; The Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, Mc Govern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Gutierrez J; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Source: International journal of stroke : official journal of the International Stroke Society [Int J Stroke] 2026 Apr; Vol. 21 (4), pp. 515-525. Date of Electronic Publication: 2025 Aug 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101274068 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4949 (Electronic) Linking ISSN: 17474930 NLM ISO Abbreviation: Int J Stroke Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multi-population genome-wide association study identifies multiple novel loci associated with asymptomatic intracranial large artery stenosis.
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  Data: <searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Khasiyev+F%22">Khasiyev F</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Spagnolo-Allende+A%22">Spagnolo-Allende A</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sanchez+DL%22">Sanchez DL</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; The Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Andrews+H%22">Andrews H</searchLink>; Biostatistics Department, Mailman School of Public Health, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Q%22">Yang Q</searchLink>; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Beiser+A%22">Beiser A</searchLink>; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Qiao+Y%22">Qiao Y</searchLink>; Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Romero+JR%22">Romero JR</searchLink>; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rundek+T%22">Rundek T</searchLink>; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.; Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Brickman+AM%22">Brickman AM</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; The Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Manly+JJ%22">Manly JJ</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; The Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Elkind+MS%22">Elkind MS</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Seshadri+S%22">Seshadri S</searchLink>; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Memory Aging and Cognition Center, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Del+Brutto+OH%22">Del Brutto OH</searchLink>; School of Medicine and Research Center, Universidad Espíritu Santo, Samborondón, Ecuador.<br /><searchLink fieldCode="AU" term="%22Hilal+S%22">Hilal S</searchLink>; Memory Aging and Cognition Center, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wasserman+BA%22">Wasserman BA</searchLink>; Johns Hopkins University School of Medicine, Baltimore, MD, USA.; University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Tosto+G%22">Tosto G</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; The Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fornage+M%22">Fornage M</searchLink>; Brown Foundation Institute of Molecular Medicine, Mc Govern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Gutierrez+J%22">Gutierrez J</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
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