Continuous infusion versus intermittent dosing of ceftazidime/avibactam in critically ill patients with Klebsiella pneumoniae OXA-48 or Pseudomonas aeruginosa infections: a single-center randomized open-label trial (ZAVICONT). Rationale and design.

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Title: Continuous infusion versus intermittent dosing of ceftazidime/avibactam in critically ill patients with Klebsiella pneumoniae OXA-48 or Pseudomonas aeruginosa infections: a single-center randomized open-label trial (ZAVICONT). Rationale and design.
Authors: Momčilović M; Department of Cardiovascular Diseases, University Hospital Centre Zagreb, Zagreb, Croatia., Šitum I; Department of Anesthesiology, Reanimatology, Intensive Medicine and Pain Therapy, University Hospital Centre Zagreb, Zagreb, Croatia., Erceg A; Department of Anesthesiology, Reanimatology, Intensive Medicine and Pain Therapy, University Hospital Centre Zagreb, Zagreb, Croatia., Siroglavić M; Department of Clinical Microbiology, Infection Prevention and Control, University Hospital Centre Zagreb, Zagreb, Croatia., Lovrić M; Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia.; University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia.; School of Medicine, University of Zagreb, Zagreb, Croatia., Nižić Nodilo L; Department of Pharmaceutical Technology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia., Hafner A; Department of Pharmaceutical Technology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia., Lovrić J; Department of Pharmaceutical Technology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia., Turčić P; Department of Pharmacology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia., Fabijanović D; Department of Cardiovascular Diseases, University Hospital Centre Zagreb, Zagreb, Croatia., Marinić A; Department of Cardiovascular Diseases, University Hospital Centre Zagreb, Zagreb, Croatia., Nedeljković V; Department of Cardiovascular Diseases, University Hospital Centre Zagreb, Zagreb, Croatia., Pašalić M; Department of Cardiovascular Diseases, University Hospital Centre Zagreb, Zagreb, Croatia., Perčin L; Department of Cardiovascular Diseases, University Hospital Centre Zagreb, Zagreb, Croatia., Šipuš D; Department of Cardiovascular Diseases, University Hospital Centre Zagreb, Zagreb, Croatia., Miličić D; Department of Cardiovascular Diseases, University Hospital Centre Zagreb, Zagreb, Croatia.; School of Medicine, University of Zagreb, Zagreb, Croatia., Lovrić D; Department of Cardiovascular Diseases, University Hospital Centre Zagreb, Zagreb, Croatia.
Source: Frontiers in pharmacology [Front Pharmacol] 2025 Aug 07; Vol. 16, pp. 1618987. Date of Electronic Publication: 2025 Aug 07 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:1663-9812
DOI:10.3389/fphar.2025.1618987