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MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing.

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Title: MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing.
Authors: Raheem IT; Merck & Co., Inc., Rahway, New Jersey, United States of America., Girijavallabhan V; Merck & Co., Inc., Rahway, New Jersey, United States of America., Fillgrove KL; Merck & Co., Inc., Rahway, New Jersey, United States of America., Goh SL; Merck & Co., Inc., Rahway, New Jersey, United States of America., Bahnck-Teets C; Merck & Co., Inc., Rahway, New Jersey, United States of America., Huang Q; Merck & Co., Inc., Rahway, New Jersey, United States of America., Li F; Merck & Co., Inc., Rahway, New Jersey, United States of America., Wan BL; Merck & Co., Inc., Rahway, New Jersey, United States of America., O'Donnell GT; Merck & Co., Inc., Rahway, New Jersey, United States of America., Patteson JB; Merck & Co., Inc., Rahway, New Jersey, United States of America., Cilento ME; Merck & Co., Inc., Rahway, New Jersey, United States of America., Bennet A; Merck & Co., Inc., Rahway, New Jersey, United States of America., Hayes RP; Merck & Co., Inc., Rahway, New Jersey, United States of America., Tummala S; Merck & Co., Inc., Rahway, New Jersey, United States of America., McHale C; Merck & Co., Inc., Rahway, New Jersey, United States of America., Wiltsie J; Merck & Co., Inc., Rahway, New Jersey, United States of America., Ellis J; Merck & Co., Inc., Rahway, New Jersey, United States of America., Asante-Appiah E; Merck & Co., Inc., Rahway, New Jersey, United States of America., Hazuda DJ; Merck & Co., Inc., Rahway, New Jersey, United States of America., Hale J; Merck & Co., Inc., Rahway, New Jersey, United States of America., Grobler JA; Merck & Co., Inc., Rahway, New Jersey, United States of America., Xu M; Merck & Co., Inc., Rahway, New Jersey, United States of America., Diamond TL; Merck & Co., Inc., Rahway, New Jersey, United States of America., Lai MT; Merck & Co., Inc., Rahway, New Jersey, United States of America.
Source: PLoS biology [PLoS Biol] 2025 Aug 26; Vol. 23 (8), pp. e3003308. Date of Electronic Publication: 2025 Aug 26 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing.
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  Data: <searchLink fieldCode="AU" term="%22Raheem+IT%22">Raheem IT</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Girijavallabhan+V%22">Girijavallabhan V</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Fillgrove+KL%22">Fillgrove KL</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Goh+SL%22">Goh SL</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Bahnck-Teets+C%22">Bahnck-Teets C</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Huang+Q%22">Huang Q</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Li+F%22">Li F</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Wan+BL%22">Wan BL</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22O'Donnell+GT%22">O'Donnell GT</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Patteson+JB%22">Patteson JB</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Cilento+ME%22">Cilento ME</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Bennet+A%22">Bennet A</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Hayes+RP%22">Hayes RP</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Tummala+S%22">Tummala S</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22McHale+C%22">McHale C</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Wiltsie+J%22">Wiltsie J</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Ellis+J%22">Ellis J</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Asante-Appiah+E%22">Asante-Appiah E</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Hazuda+DJ%22">Hazuda DJ</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Hale+J%22">Hale J</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Grobler+JA%22">Grobler JA</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Diamond+TL%22">Diamond TL</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Lai+MT%22">Lai MT</searchLink>; Merck & Co., Inc., Rahway, New Jersey, United States of America.
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  Data: <searchLink fieldCode="JN" term="%22101183755%22">PLoS biology</searchLink> [PLoS Biol] 2025 Aug 26; Vol. 23 (8), pp. e3003308. <i>Date of Electronic Publication: </i>2025 Aug 26 (<i>Print Publication: </i>2025).
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