Targeting pyruvate metabolism generates distinct CD8+ T cell responses to gammaherpesvirus and B lymphoma.

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Title: Targeting pyruvate metabolism generates distinct CD8+ T cell responses to gammaherpesvirus and B lymphoma.
Authors: Kang T; Microbiology and Immunology Department, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA., Usherwood YK; Microbiology and Immunology Department, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA., Reisz JA; Metabolomics core, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Kamerkar SC; Department of Biochemistry and Cell Biology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA., Culp-Hill R; Metabolomics core, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Wilkins OM; Genomics and Molecular Biology Shared Resource, Dartmouth Cancer Center, Lebanon, New Hampshire, USA.; Department of Biomedical Data Science, Geisel School of Medicine, and., Verissimo AF; Institute for Molecular Targeting, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA., Kolling FW 4th; Genomics and Molecular Biology Shared Resource, Dartmouth Cancer Center, Lebanon, New Hampshire, USA., Hung AM; Genomics and Molecular Biology Shared Resource, Dartmouth Cancer Center, Lebanon, New Hampshire, USA., Musial SC; Microbiology and Immunology Department, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA., Rosato PC; Microbiology and Immunology Department, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA., D'Alessandro A; Metabolomics core, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Higgs HN; Department of Biochemistry and Cell Biology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA., Usherwood EJ; Microbiology and Immunology Department, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA.
Source: JCI insight [JCI Insight] 2025 Aug 22; Vol. 10 (16). Date of Electronic Publication: 2025 Aug 22 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2379-3708
DOI:10.1172/jci.insight.187680