Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement.
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| Title: | Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement. |
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| Authors: | Mikami T; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kato I; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. itarkt@kuhp.kyoto-u.ac.jp., Nishimura A; Department of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan., Eguchi-Ishimae M; Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan., Kamitori T; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Tasaka K; Department of Pediatrics, Kurashiki Central Hospital, Okayama, Japan., Kubota H; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Isobe T; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Uchihara Y; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Namikawa Y; Department of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan., Hamada S; Department of Child Health and Welfare, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan., Tsujimoto S; Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Inoue S; Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.; Department of Hematology and Oncology, Kobe Children's Hospital, Kobe, Japan., Hamabata T; Department of Pediatrics, Kurashiki Central Hospital, Okayama, Japan., Izawa K; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Miyamura T; Department of Pediatrics, the University of Osaka Graduate School of Medicine, Osaka, Japan., Tomizawa D; Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Imamura T; Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan., Toyoda H; Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan., Eguchi M; Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan., Goto H; Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan., Ogawa S; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto, Japan.; Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden., Takagi M; Department of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan., Wing JB; Laboratory of Human Single Cell Immunology, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan.; Human Single Cell Immunology Team, Center for Infectious Disease Education and Research (CiDER), Osaka University, Osaka, Japan.; Center for Advanced Modalities and DDS (CAMaD), Osaka University, Osaka, Japan., Takita J; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. jtakita@kuhp.kyoto-u.ac.jp. |
| Source: | Nature communications [Nat Commun] 2025 Aug 26; Vol. 16 (1), pp. 7955. Date of Electronic Publication: 2025 Aug 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-63271-y |
