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Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement.

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Title: Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement.
Authors: Mikami T; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kato I; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. itarkt@kuhp.kyoto-u.ac.jp., Nishimura A; Department of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan., Eguchi-Ishimae M; Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan., Kamitori T; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Tasaka K; Department of Pediatrics, Kurashiki Central Hospital, Okayama, Japan., Kubota H; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Isobe T; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Uchihara Y; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Namikawa Y; Department of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan., Hamada S; Department of Child Health and Welfare, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan., Tsujimoto S; Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Inoue S; Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.; Department of Hematology and Oncology, Kobe Children's Hospital, Kobe, Japan., Hamabata T; Department of Pediatrics, Kurashiki Central Hospital, Okayama, Japan., Izawa K; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Miyamura T; Department of Pediatrics, the University of Osaka Graduate School of Medicine, Osaka, Japan., Tomizawa D; Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Imamura T; Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan., Toyoda H; Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan., Eguchi M; Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan., Goto H; Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan., Ogawa S; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto, Japan.; Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden., Takagi M; Department of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan., Wing JB; Laboratory of Human Single Cell Immunology, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan.; Human Single Cell Immunology Team, Center for Infectious Disease Education and Research (CiDER), Osaka University, Osaka, Japan.; Center for Advanced Modalities and DDS (CAMaD), Osaka University, Osaka, Japan., Takita J; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. jtakita@kuhp.kyoto-u.ac.jp.
Source: Nature communications [Nat Commun] 2025 Aug 26; Vol. 16 (1), pp. 7955. Date of Electronic Publication: 2025 Aug 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement.
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  Data: <searchLink fieldCode="AU" term="%22Mikami+T%22">Mikami T</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+I%22">Kato I</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. itarkt@kuhp.kyoto-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Nishimura+A%22">Nishimura A</searchLink>; Department of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Eguchi-Ishimae+M%22">Eguchi-Ishimae M</searchLink>; Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Kamitori+T%22">Kamitori T</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Tasaka+K%22">Tasaka K</searchLink>; Department of Pediatrics, Kurashiki Central Hospital, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Kubota+H%22">Kubota H</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Isobe+T%22">Isobe T</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Uchihara+Y%22">Uchihara Y</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Namikawa+Y%22">Namikawa Y</searchLink>; Department of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hamada+S%22">Hamada S</searchLink>; Department of Child Health and Welfare, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.<br /><searchLink fieldCode="AU" term="%22Tsujimoto+S%22">Tsujimoto S</searchLink>; Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Inoue+S%22">Inoue S</searchLink>; Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.; Department of Hematology and Oncology, Kobe Children's Hospital, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Hamabata+T%22">Hamabata T</searchLink>; Department of Pediatrics, Kurashiki Central Hospital, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Izawa+K%22">Izawa K</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Miyamura+T%22">Miyamura T</searchLink>; Department of Pediatrics, the University of Osaka Graduate School of Medicine, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Tomizawa+D%22">Tomizawa D</searchLink>; Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Imamura+T%22">Imamura T</searchLink>; Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Toyoda+H%22">Toyoda H</searchLink>; Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan.<br /><searchLink fieldCode="AU" term="%22Eguchi+M%22">Eguchi M</searchLink>; Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Goto+H%22">Goto H</searchLink>; Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Ogawa+S%22">Ogawa S</searchLink>; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto, Japan.; Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Takagi+M%22">Takagi M</searchLink>; Department of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Wing+JB%22">Wing JB</searchLink>; Laboratory of Human Single Cell Immunology, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan.; Human Single Cell Immunology Team, Center for Infectious Disease Education and Research (CiDER), Osaka University, Osaka, Japan.; Center for Advanced Modalities and DDS (CAMaD), Osaka University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Takita+J%22">Takita J</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. jtakita@kuhp.kyoto-u.ac.jp.
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