Helicobacter hepaticus promotes hepatic steatosis through CdtB-induced mitochondrial stress and lipid metabolism reprogramming.

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Title: Helicobacter hepaticus promotes hepatic steatosis through CdtB-induced mitochondrial stress and lipid metabolism reprogramming.
Authors: Jin S; Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.; Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China., Zhu L; Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China. zhuliqi@yzu.edu.cn.; Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China. zhuliqi@yzu.edu.cn., Bao R; Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.; Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China., Yang L; Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.; Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China., Zhuang T; Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.; Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China., Lian L; MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China., Wang T; Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.; Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China., Yin J; Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.; Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China., Zhang S; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China., Zhou L; Shanghai Immune Therapy Institute, Shanghai Jiaotong University School of Medicine-affiliated Renji Hospital, Shanghai, China., Zheng M; MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. zhengmh@wmu.edu.cn.; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China. zhengmh@wmu.edu.cn., Zhang Q; Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China. zquan@yzu.edu.cn.; Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China. zquan@yzu.edu.cn.
Source: Nature communications [Nat Commun] 2025 Aug 26; Vol. 16 (1), pp. 7954. Date of Electronic Publication: 2025 Aug 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-63351-z