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NF1-depleted ER+ breast cancers are differentially sensitive to CDK4/6 inhibitors.

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Title: NF1-depleted ER+ breast cancers are differentially sensitive to CDK4/6 inhibitors.
Authors: Zheng ZY; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA., Chen A; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Jaehnig EJ; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Anurag M; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA., Lei JT; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Feng L; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Wang C; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Fandino D; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Singh P; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Kennedy H; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Yadav G; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Vollert CT; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Tsai J; Guardant Health, Palo Alto, CA 94304, USA., Chen X; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Li Y; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Lim B; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Thompson A; Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA., Li S; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Foulds CE; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA., Zhang B; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Ellis MJ; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Guardant Health, Palo Alto, CA 94304, USA., Chang EC; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Aug 27; Vol. 17 (813), pp. eadq5492. Date of Electronic Publication: 2025 Aug 27.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: NF1-depleted ER<superscript>+</superscript> breast cancers are differentially sensitive to CDK4/6 inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Zheng+ZY%22">Zheng ZY</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Chen+A%22">Chen A</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Jaehnig+EJ%22">Jaehnig EJ</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Anurag+M%22">Anurag M</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Lei+JT%22">Lei JT</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Feng+L%22">Feng L</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Fandino+D%22">Fandino D</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Singh+P%22">Singh P</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Kennedy+H%22">Kennedy H</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Yadav+G%22">Yadav G</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Vollert+CT%22">Vollert CT</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Tsai+J%22">Tsai J</searchLink>; Guardant Health, Palo Alto, CA 94304, USA.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Lim+B%22">Lim B</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+A%22">Thompson A</searchLink>; Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Foulds+CE%22">Foulds CE</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Ellis+MJ%22">Ellis MJ</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Guardant Health, Palo Alto, CA 94304, USA.<br /><searchLink fieldCode="AU" term="%22Chang+EC%22">Chang EC</searchLink>; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 Aug 27; Vol. 17 (813), pp. eadq5492. <i>Date of Electronic Publication: </i>2025 Aug 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
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