UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation.
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| Title: | UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation. |
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| Authors: | Loix M; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Vanherle S; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Bolkaerts L; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Verberk SGS; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Punt M; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Rotterdam, The Netherlands., Wouters F; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Moonen B; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Verhagen R; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Rotterdam, The Netherlands., Van Wouw SAE; Department of Medical Biochemistry, Amsterdam University Medical Center, Amsterdam Institutes of Cardiovascular Sciences and Gastroenterology Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Jongejan A; Bioinformatics Laboratory, Academic University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Distel B; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Rotterdam, The Netherlands., Elgersma Y; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Rotterdam, The Netherlands., Haidar M; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Zelcer N; Department of Medical Biochemistry, Amsterdam University Medical Center, Amsterdam Institutes of Cardiovascular Sciences and Gastroenterology Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Hendriks JJA; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Bogie JFJ; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium. jeroen.bogie@uhasselt.be.; University MS Center Hasselt, Pelt, Belgium. jeroen.bogie@uhasselt.be. |
| Source: | Nature communications [Nat Commun] 2025 Aug 29; Vol. 16 (1), pp. 8077. Date of Electronic Publication: 2025 Aug 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-62053-w |
