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UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation.

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Title: UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation.
Authors: Loix M; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Vanherle S; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Bolkaerts L; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Verberk SGS; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Punt M; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Rotterdam, The Netherlands., Wouters F; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Moonen B; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Verhagen R; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Rotterdam, The Netherlands., Van Wouw SAE; Department of Medical Biochemistry, Amsterdam University Medical Center, Amsterdam Institutes of Cardiovascular Sciences and Gastroenterology Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Jongejan A; Bioinformatics Laboratory, Academic University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Distel B; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Rotterdam, The Netherlands., Elgersma Y; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Rotterdam, The Netherlands., Haidar M; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Zelcer N; Department of Medical Biochemistry, Amsterdam University Medical Center, Amsterdam Institutes of Cardiovascular Sciences and Gastroenterology Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Hendriks JJA; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium., Bogie JFJ; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium. jeroen.bogie@uhasselt.be.; University MS Center Hasselt, Pelt, Belgium. jeroen.bogie@uhasselt.be.
Source: Nature communications [Nat Commun] 2025 Aug 29; Vol. 16 (1), pp. 8077. Date of Electronic Publication: 2025 Aug 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation.
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  Data: <searchLink fieldCode="AU" term="%22Loix+M%22">Loix M</searchLink>; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium.<br /><searchLink fieldCode="AU" term="%22Vanherle+S%22">Vanherle S</searchLink>; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium.<br /><searchLink fieldCode="AU" term="%22Bolkaerts+L%22">Bolkaerts L</searchLink>; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium.<br /><searchLink fieldCode="AU" term="%22Verberk+SGS%22">Verberk SGS</searchLink>; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium.<br /><searchLink fieldCode="AU" term="%22Punt+M%22">Punt M</searchLink>; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wouters+F%22">Wouters F</searchLink>; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium.<br /><searchLink fieldCode="AU" term="%22Moonen+B%22">Moonen B</searchLink>; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium.<br /><searchLink fieldCode="AU" term="%22Verhagen+R%22">Verhagen R</searchLink>; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Van+Wouw+SAE%22">Van Wouw SAE</searchLink>; Department of Medical Biochemistry, Amsterdam University Medical Center, Amsterdam Institutes of Cardiovascular Sciences and Gastroenterology Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jongejan+A%22">Jongejan A</searchLink>; Bioinformatics Laboratory, Academic University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Distel+B%22">Distel B</searchLink>; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Elgersma+Y%22">Elgersma Y</searchLink>; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Haidar+M%22">Haidar M</searchLink>; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium.<br /><searchLink fieldCode="AU" term="%22Zelcer+N%22">Zelcer N</searchLink>; Department of Medical Biochemistry, Amsterdam University Medical Center, Amsterdam Institutes of Cardiovascular Sciences and Gastroenterology Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hendriks+JJA%22">Hendriks JJA</searchLink>; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.; University MS Center Hasselt, Pelt, Belgium.<br /><searchLink fieldCode="AU" term="%22Bogie+JFJ%22">Bogie JFJ</searchLink>; Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium. jeroen.bogie@uhasselt.be.; University MS Center Hasselt, Pelt, Belgium. jeroen.bogie@uhasselt.be.
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