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Replication of blood DNA methylomic signatures associated with cerebrospinal fluid levels of YKL-40 and NfL biomarkers.

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Title: Replication of blood DNA methylomic signatures associated with cerebrospinal fluid levels of YKL-40 and NfL biomarkers.
Authors: Kaleck T; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany., Campos-Martin R; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Cano A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), National Institute of Health Carlos III, Madrid, Spain., Fernández MV; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain., Martino-Adami P; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Kleineidam L; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, Bonn, Germany., Fuentes VMA; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Tripathi KP; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Parveen K; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany., Puerta R; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; PhD Program in Biotechnology, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain., de Rojas I; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg., Ravichandran KA; German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, Bonn, Germany., Peters O; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; ECRC Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany., Hellmann-Regen J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; ECRC Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany., Priller J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.; Department of Psychiatry and Psychotherapy and German Center for Mental Health (DZPG), School of Medicine and Health, Technical University of Munich, Munich, Germany.; University of Edinburgh and UK Dementia Research Institute, London, UK., Gemenetzi M; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany., Schneider A; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, Bonn, Germany., Wiltfang J; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany.; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Campus Universitario de Santiago, Aveiro, Portugal., Düzel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany., Buerger K; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Perneczky R; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.; Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK., Teipel S; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Laske C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Brosseron F; German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, Bonn, Germany., Marquié M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), National Institute of Health Carlos III, Madrid, Spain., van den Hove D; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands., Boada M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), National Institute of Health Carlos III, Madrid, Spain., Heneka MT; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, Bonn, Germany.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg., Wagner M; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, Bonn, Germany., Marchant N; Division of Psychiatry, University College London, London, UK., Lambert JC; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Frikke-Schmidt R; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen N, Denmark., Jessen F; German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, Bonn, Germany.; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Ruiz A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), National Institute of Health Carlos III, Madrid, Spain.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA., Ramirez A; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany.; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Sep; Vol. 21 (9), pp. e70647.
Publication Type: Letter
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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Description
ISSN:1552-5279
DOI:10.1002/alz.70647