A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite.

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Title: A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite.
Authors: Wu Y; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Völler S; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Goulooze SC; Leiden Experts on Advanced Pharmacokinetics and Pharmacodynamics (LAP&P) Consultants BV, Leiden, The Netherlands., Allegaert K; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Development and Regeneration, and Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium., Sherwin CMT; Internal Medicine, UWA Medical School, The University of Western Australia, Perth, Western Australia, Australia.; Differentia Biotech Ltd, CA, USA., van Rongen A; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., W E Roofthooft D; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Simons SHP; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Tibboel D; Department of Pediatric Surgery, Erasmus University MC-Sophia Children's Hospital, Rotterdam, The Netherlands., Flint RB; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands., van den Anker JN; Division of Clinical Pharmacology, Children's National Hospital, Washington, DC, USA., Knibbe CAJ; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.; Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands.
Source: Journal of clinical pharmacology [J Clin Pharmacol] 2025 Dec; Vol. 65 (12), pp. 1829-1843. Date of Electronic Publication: 2025 Sep 05.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1552-4604
DOI:10.1002/jcph.70080