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A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite.

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Title: A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite.
Authors: Wu Y; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Völler S; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Goulooze SC; Leiden Experts on Advanced Pharmacokinetics and Pharmacodynamics (LAP&P) Consultants BV, Leiden, The Netherlands., Allegaert K; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Development and Regeneration, and Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium., Sherwin CMT; Internal Medicine, UWA Medical School, The University of Western Australia, Perth, Western Australia, Australia.; Differentia Biotech Ltd, CA, USA., van Rongen A; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., W E Roofthooft D; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Simons SHP; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Tibboel D; Department of Pediatric Surgery, Erasmus University MC-Sophia Children's Hospital, Rotterdam, The Netherlands., Flint RB; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands., van den Anker JN; Division of Clinical Pharmacology, Children's National Hospital, Washington, DC, USA., Knibbe CAJ; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.; Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands.
Source: Journal of clinical pharmacology [J Clin Pharmacol] 2025 Dec; Vol. 65 (12), pp. 1829-1843. Date of Electronic Publication: 2025 Sep 05.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE
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  Data: A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite.
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  Data: <searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Völler+S%22">Völler S</searchLink>; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Goulooze+SC%22">Goulooze SC</searchLink>; Leiden Experts on Advanced Pharmacokinetics and Pharmacodynamics (LAP&P) Consultants BV, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Allegaert+K%22">Allegaert K</searchLink>; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Development and Regeneration, and Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Sherwin+CMT%22">Sherwin CMT</searchLink>; Internal Medicine, UWA Medical School, The University of Western Australia, Perth, Western Australia, Australia.; Differentia Biotech Ltd, CA, USA.<br /><searchLink fieldCode="AU" term="%22van+Rongen+A%22">van Rongen A</searchLink>; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22W+E+Roofthooft+D%22">W E Roofthooft D</searchLink>; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Simons+SHP%22">Simons SHP</searchLink>; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Tibboel+D%22">Tibboel D</searchLink>; Department of Pediatric Surgery, Erasmus University MC-Sophia Children's Hospital, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Flint+RB%22">Flint RB</searchLink>; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Anker+JN%22">van den Anker JN</searchLink>; Division of Clinical Pharmacology, Children's National Hospital, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Knibbe+CAJ%22">Knibbe CAJ</searchLink>; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.; Department of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.; Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands.
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              Text: 2025 Dec
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